It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Dispute over Manichester now ‘resolved’, say Mounfield family
Danny Jones
The family of the late, great Manchester musician, Gary ‘Mani’ Mounfield, have said that the drama surrounding the highly-anticipated tribute festival in his name, Manichester, has now thankfully been settled.
Now the focus can once again return to remembering him as best as possible.
Following plenty of talk about the project following his passing late last year, a live music festival honouring Mani was finally confirmed in March, and the reaction following the event’s announcement has been unsurprisingly phenomenal.
Well, at least for the most part, as there was also some confusion over whether or not Manichester was still a charitable effort as advertised, with son Gene Mounfield disputing claims online. Fortunately, it all seems to have been put to bed now.
On behalf of the boys, and as their legal guardian, I want to thank everyone for the kind messages and concern for their wellbeing. There was a misunderstanding regarding the upcoming Manichester tribute concert, but we’re pleased to share that everything has now been resolved. pic.twitter.com/j8jEMrFzsD
Being organised by Madchester.com and locally-founded fashion label, GIOGOI, the debut edition was said to have the total blessing of Mani’s family, including his brother, Greg Mounfield.
It was also said that the funds raised by the show would be going to the legendary Stone Roses and Primal Scream bassists’ twins, George and Grene, but the latter recently argued that “nothing” was going to either him or his brother and that the news was “dropped” the plans just a fortnight prior.
He also said that “if it was a charity gig it would be at Co-op [Live] or Heaton Park, and it would be done by SJM [Concerts]”: a Manchester-based promoters and events company.
All of this was also wrapped up in ever more paper talk and sensationalism, as some were reporting that Noel and Liam Gallagher, as well as other members of Oasis, would be surprising fans as the still yet to be revealed ‘major headliner’.
These rumours have since been quashed, as has whatever miscommunication caused the misunderstanding between the parties concerned, and we are now back to simply looking forward to seeing an already stacked lineup here in the city centre this May.
As for the surviving Mounfields, they went on to add in an accompanying Instagram post: “We would also like to express our gratitude to PH.
“It means a great deal to all of us that so many people loved Mani enough to give their time and energy to honour his memory in this way. We are genuinely touched by the support.
“It has been an incredibly difficult few years for the boys and for our whole family. We hope this event will bring some much‑needed joy and create new, positive memories for everyone who cared about him.
“With love and thanks – The Family”
It goes without saying that we can’t wait for this city and Greater Manchester as a whole to honour a Manc icon and are looking forward to another year celebrating the thing that never fails to bring us all together: music.
Featured Images — livepict.com (via Wikimedia Commons)/Publicity pictures (supplied)
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Rochdale is bidding to become the UK’s first-ever Town of Culture in 2028
Emily Sergeant
Rochdale has announced its intention to bid to become UK Town of Culture 2028.
Entering into the national competition launched by the Department for Culture, Media and Sport (DCMS), following on from the success of the already-existing City of Culture award, the Greater Manchester town is hoping to be the first-ever town to claim the title.
The Town of Culture competition invites towns across the UK to showcase their cultural story and develop ambitious programmes that celebrate local heritage, creativity, and communities.
The winning town receives a £3 million grant from the Government to deliver a major year-long cultural programme in 2028 designed to boost civic pride, attract visitors, and provide everyone with the opportunity to participate in cultural activities.
Rochdale’s bid is being led by Rochdale Borough Council and Rochdale Development Agency, alongside cultural groups, education providers, and community organisations.
The bid will build on the town’s history as the birthplace of the Co-operative movement, and a centre of political reform, collective action and working-class cultural innovation.
A town of national and international significance, whose people and ideas have shaped the social, democratic and cultural life of the UK and beyond, Rochdale Council says the town’s story is ‘distinctive’ and as highly relevant today as it ever has been, and this is a driving force behind its Town of Culture 2028 bid.
Not just historically, but over recent years too, the town has made a significant contribution to the UK’s popular culture, producing internationally recognised musicians, artists, writers, and performers.
Local leaders say the bid to become the UK’s first ever Town of Culture underlines Rochdale’s ambition after just completing a ‘hugely successful’ year as Greater Manchester Town of Culture for 2025.
Rochdale is bidding to become the UK’s first-ever Town of Culture / Credit: The Manc Group | Rochdale Council
“We have a strong foundation for a bold and future focused UK Town of Culture programme and an incredible story to tell,” commented Cllr Neil Emmott, who is the Leader of Rochdale Borough Council.
“We’ll be developing a fabulous programme of new events and activities as well as amplifying our existing offer and recently transformed town hall square and centre.
“As we have already seen during our year as Greater Manchester Town of Culture, we have an established infrastructure of creative partners ready to go, who have already expressed their support for our bid, providing significant capacity and scale to deliver a UK town of culture programme in 2028 that would leave a permanent cultural legacy.
“We have exciting and varied attractions and iconic venues that have seen significant investment, an array of creative talent and we’re very well connected.
“This bid will allow us to share this in new ways and invite others to experience it.”
The Manc -
2nd December 2021 
