It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Elbow teams up with Co-op Live to donate equipment to Manchester grassroots venues
Thomas Melia
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Bury band Elbow have joined forces with Manchester’s biggest indoor arena, Co-op Live, in aid of supporting local grassroots venues.
The funds will help improve the already incredible music scene in Manchester, benefitting staples likes Night and Day Café, Matt and Phred’s Jazz Club, SOUP and more.
All of the donations will be distributed across six independent music venues and will be used for various instruments, PA equipment, backline technology and other necessities depending on the requirements of each site.
Elbow have teamed up with Co-op Live in aid of supporting Manchester grassroots venues.Credit: Supplied
This initiative has been keeping Manchester’s Northern Quarter in the forefront of people’s minds when it comes to live music as well as the impressive Co-op Live.
Alongside providing vital resources for these local institutions, Elbow teaming up with Co-op Live also helps cement the North West as one of the main powerhouses in relation to live music.
The latest efforts from the largest indoor arena in Manchester fall in line with celebrating one year of bringing some of the best live music to the city, being officially open for 12 months in May.
Co-op Live have made a commitment to the people and the planet, promising to donate £1 million annually to the Co-op Foundation.
The stunning Co-op Live venue, Manchester’s largest indoor arena.Elbow performing at Co-op Live, marking history as the first act to grace the venue.Credit: Audio North/Supplied
Manchester’s latest live music venue also contributed significantly to selected charities, including Happy Doggo – chosen by Liam Gallagher and Eric Clapton’s addiction recovery centre, Crossroads.
As Elbow teams up with Co-op Live, even more money is making its way to necessary resources, this time in the likes of crucial live music establishments.
Elbow front-person Guy Garvey says: “Playing Co-op Live’s opening night will stay with us for a lifetime, not least because of how incredible the room sounded.”
“When the venue donated funds in our name to support the city we love, it made complete sense to carry that through to the Northern Quarter and to venues that have meant so much to my bandmates and I throughout our career.”
Guy Dunstan, Senior Vice President and General Manager, Co-op Live, adds: “In the past year, I have been proud to see Co-op Live become an integral part of such an incredible city.”
“Teaming up with Elbow to directly support the venues that first put Manchester on the map, and to share something so intrinsic to us as venues – proper sound – is something truly special.”
Police launch investigation after a 19-year-old is stabbed in broad daylight at an Oldham retail park
Emily Sergeant
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A police investigation has been launched after a stabbing in a ‘very public place’ in Oldham yesterday afternoon.
Greater Manchester Police (GMP) explained that officers were called out to Alexandra Retail Park in Oldham yesterday afternoon ( Sunday 30 March 2025) at 3:25pm, and when they arrived on the scene, they found that a 19-year-old man had been stabbed.
The victim was taken to hospital with ‘serious injuries’, and GMP assures that he and his family are being supported at this time.
A scene remains in place at the retail park and some of the surrounding areas while the investigation is ongoing, and a large police presence can also been seen too as officers continue to collect evidence and piece together the events of what happened.
Police also believe the attack to be an ‘isolated incident’ with those involved known to each other, indicating no threat to the wider public.
“We understand this incident is shocking and took place in a very public space,” commented Inspector Andrew Clayton.
“There have been no arrests so far, but enquiries are ongoing to determine who is responsible. At this stage, we do believe the attack to be an isolated incident involving those known to one another.”
Alexandra Retail Park, where the incident occurred yesterday afternoon / Credit: Google Maps
In a bid to gather as much information as possible, a public police appeal has been made.
Inspector Clayton continues: “We have spoken to a number of witnesses so far, but would encourage anyone who believes they have any information or dash cam footage which could assist our investigation, particularly that which may help us identify the perpetrators, to come forward.”
Anyone with any information is asked to contact GMP on 101, quoting log 1757 of 30/03/25, or by getting in touch with Crimestoppers anonymously on 0800 555 111.