An eight-year-old Cheshire girl with a rare degenerative disease has become one of the first to receive a pioneering new treatment that will attempt to save her eyesight.
Amelia Carroll, from Poynton near Stockport, was diagnosed with CLN2 Batten disease – an incurable and fatal condition that affects roughly around 30-50 children in the UK – when she was just two.
The disease is caused by a change in a gene that is responsible for making a specific enzyme in the nervous system, and it results in seizures, a gradual decline in a child’s ability to walk, speak and see, as well as progressive dementia.
Amelia’s 11-year-old brother Ollie also has the same condition, yet has sadly already lost his eyesight.
“We have watched our son Ollie go blind, and now the same is starting to happen to Amelia,” mother Lucy Carroll explained, which is why her and her husband Mike decided to contribute to a fundraising campaign together with families of other children affected by the disease alongside the Battens Disease Family Association (BDFA) to help fund a world-first trail of a groundbreaking new treatment at Great Ormond Street Hospital (GOSH).
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Over £200,000 was raised through the campaign, and clinicians and researchers at GOSH and ICH say the treatment programme has the potential to transform the quality of life for children living with CLN2 Batten disease.
Amelia became one of the first children in the world to receive the treatment, and is said to already be responding to it “perfectly”, CheshireLive reports.
For the past two years, enzyme replacement therapy has been used to help prevent neurological deterioration in children with CLN2 disease. The drug, called Brineura, was first approved for use on the NHS in 2019 and is administered directly into the brain by a regular infusion.
It has shown to restore enzyme activity and slow the onset of disability.
However, this infusion into the brain does not prevent children going blind, as the enzyme cannot cross the blood-retina barrier, and this means that the nerves in the eye cannot function and vision is lost, which is why clinicians and researchers at GOSH and ICH are trying a the treatment to prevent the onset of blindness instead.
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To do this, GOSH said they are using the tiny amount of the drug leftover from the brain infusion and injecting it directly into the back of the eye.
The 18-month treatment trail – which is said to be being given on a compassionate use basis – hopes to prevent eyesight deterioration in children by providing the enzyme that the nerves in the back of the eye need to function.
Ms Carroll said “to save a child’s sight would be incredible”, and if it does indeed work, it would “make such a big difference to Amelia’s quality of life”.
“We just pray it works,” she added.
Speaking on the groundbreaking treatment trail, Professor Paul Gissen, from GOSH and the UCL GOS Institute of Child Health, said: “If successful, we hope our work can pave the way to saving the sight of more children with this disease to preserve their quality of life for as long as possible.”
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Amelia’s father, Mike Carroll, said the “amazing” nurses and doctors treating his daughter were “incredible”.
Police appeal for witnesses following rape of teenage boy in Manchester’s Printworks
Emily Sergeant
An urgent appeal for information and witnesses has been made following the rape of a teenage boy in Manchester city centre last week.
Greater Manchester Police (GMP) is currently investigating the rape and serious assault of a teenager.
The male victim – who is aged under 18, and has therefore not been publicly named – arranged to meet a man via social media, and was attacked in the toilets of a venue on Dantzic Street inside Printworks at around 5pm last Friday (24 April 2026).
The victim has described the suspect as an Asian male aged between 18 and 20, of slim build, with a goatee beard, black hair parted in the centre and covering his forehead, and at the time of the incident, he was said to be wearing a black puffy coat, dark jeans, white-and-black trainers, and glasses.
Police arrested a 19-year-old man on suspicion of rape over the weekend, but he has since been bailed pending further enquiries.
With the investigation proceeding at pace, police are now asking for the public for their help and, in particular, appealing for potential witnesses who was in the area at the time.
“We have committed a large number of officers from across the force to the investigation and are carrying out extensive forensic and CCTV enquiries,” explained Detective Chief Inspector Chris Woodburn, from GMP’s City of Manchester CID.
“We are appealing for anyone who was in the Printworks area at the time of the incident to come forward. This would have been a busy time of day when there would have been a lot of people around.
“We also believe there may have been a second man in or around the toilets in a licensed premises off Dantzic Street at the time of the incident, and we want to speak to him as a witness as we believe he may have vital information that could assist with our investigation.”
Can you help? Anyone with information or who was in the area at the time is urged to call GMP’s dedicated team on 0161 856 4259, on 101, or via LiveChat online quoting log 2647 of 24/4/26.
You can also call Crimestoppers anonymously on 0800 555 111.
Featured Image – GMP
News
‘Stunning’ Old Rectory pub in Stockport suffers permanent closure
Danny Jones
One of Stockport town centre’s most beautiful pub venues, The Old Rectory, has officially closed down permanently following notices about its “final stages”.
Built circa 1740, the historic space itself has been there since before the Regency period.
Stockport‘s Old Rectory pub on Churchgate has been a number of different things over the decades, and has changed hands multiple times in more recent years, but now the Greene King site has shut down, what seems like, for good.
In fact, if you look online, it is already listed as ‘permanently closed’ on Google, as does a temporary sign now stuck to the gates of their entrance, with the most recent service last week being their final one.
With the news having since been shared on the Stockport Tourism notice board on Facebook, a post from the ‘Old Rec’ team reads: “We are sad to announce that The Old Rectory will be closing its doors at the end of this month. Thank you to everyone who has visited and supported the venue over the years.”
An update has also now been shared on the official CAMRA (Campaign for Real Ale) website.
Issuing a statement directly to The Manc, a spokesperson for Greene King said: “Following a period of team member consultation, we can confirm that the Old Rectory has now closed.
“We are grateful to everyone who has supported the Old Rectory over the years, and we look forward to welcoming them into our other pubs in the local area soon.”
They also go on to assure that they have worked with the team members who have sadly been put out of work to try and find new positions at other locations, with the operators urging Stopfordians to try other nearby pubs such as Gardeners Arms in Offerton and the recently refurbished Carousel in Reddish.
Described by CAMRA as a “multi-roomed pub-restaurant that still maintains a country house feel with plenty of dark wood and plush décor”, not to mention praising the all-day food service and “top notch” beer selection, its heyday may have been long ago, but it’ll still be missed by regulars and natives.
It’s also worth noting that the former Hungry Horse public house also long-served as an accommodation spot, too, with Premier Inn’s ‘Stockport Central Hotel’ attached to the back of the building.
There are no updates on this front at present, and they could easily repurpose what natives have hailed as a “stunning” Georgian structure – not to mention the expansive garden grounds – but the company is also currently cutting more than 3,800 jobs as part of a wider savings strategy.
Elsewhere, as SK residents bid goodbye to one veteran pub, they’re also gearing up to welcome back another former favourite…
Emily Sergeant -
14th January 2022 
