Greater Manchester Police have recovered £7.5m worth of counterfeit items in Cheetham Hill.
More than 100 officers raided three premises on Wednesdat in one of the largest operations ever carried out by GMP.
Clothes, perfume, watches and handbags were found at the scene.
15 people have been arrested, with 11 facing charges for distribution of counterfeit goods and/or immigration offences.
Phil Lewis, Director General of the Anti-Counterfeiting Group, commented: "These Manchester traders selling counterfeit goods are blatantly defrauding consumers.
"They're harming legitimate businesses and making absolutely no contribution toward public services or the UK economy."
"We urge consumers to stop buying goods from these types of premises and think twice about the goods they buy online, because counterfeit goods are often of poor quality and, more worryingly, can be unsafe and even dangerous."
Police also seized mobile phones and cash during the raids.
Investigations are still ongoing.