A 'gang of thugs' committed seven separate robberies in the Northern Quarter on Sunday evening leaving five people hospitalised.
The attacks happened in the early hours (between 2am and 4am) by three men, the police have confirmed.
The victims were punched 'without warning' before having items taken off them and a total of five people aged between 20 and 60 were rushed to hospital following the attacks.
It has been confirmed that one of the victims suffered a broken jaw, however, while some of the victims remain in hospital it is unclear how serious their injuries are.
The attacks took place on Oldham Street, Tib Street, Piccadilly Gardens, High Street and Newton Street and it's thought that they were carried out by a gang who regularly operate in this area.
Det Sgt Kat McKeown of GMP’s City of Manchester Division said: "This was a series of violent robberies during which victims have been set upon by three men intent on causing them harm.
“I’d like to assure the public that we’re currently working to identify those responsible and I’d ask that anyone with information contact police.
“We wish those who remain in hospital a speedy recovery from their injuries.”