It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
News
‘Eyesore’ Northern Quarter car park to be redeveloped as ambitious new neighbourhood
Emily Sergeant
An underused multi-storey car park in the heart of the city centre is set to be sold and redeveloped as an ‘ambitious’ new neighbourhood.
The ‘eyesore’ car park situated in Manchester’s iconic Northern Quarter will be transformed into what Manchester City Council is hoping will become a green and sustainable neighbourhood set to complement the ‘unique and independent’ ethos of the area.
It comes after developers CBRE were appointed by the Council last year to market the Church Street site for disposal, ahead of seeking formal planning permission.
The new scheme will deliver more than 300 new homes – including 60 affordable homes – alongside new commercial opportunities and high-quality public spaces.
A before and proposed after of Church Street Car Park / Credit: Manchester City Council
It’s expected that the development will respect the heritage and architecture of the historic city centre neighbourhood and help to enhance the wider area, all while improving a car park site that has long fallen out of favour.
The new neighbourhood will also feature four new public squares and green spaces, along with opportunities for pedestrianising the surrounding streets as part of the public realm.
As mentioned, commercial space is also part of the plans, as the ground floor of the building will offer a mix of smaller, more affordable units to ensure local independent businesses can access the neighbourhood, alongside units for food and beverage outlets.
“For too long, the Church Street car park has been an eyesore and a barrier to the ongoing success of the Northern Quarter,” commented Cllr Bev Craig, who is the Leader of Manchester City Council.
“We want to bring forward a world-class development that has the potential to completely transform this part of the neighbourhood, together with the newest city centre public squares and green spaces.”
The final legal negotiations will conclude over the summer, and it’s expected that a public consultation will then take place to inform a future planning application.
Featured Image – Manchester City Council
News
‘Major milestone’ as planning permission secured to transform Oldham town centre
Emily Sergeant
Planning permission has been granted for six transformational sites in Oldham town centre, with developers calling it a ‘major milestone’.
This approval marks a key step forward in Muse Places and Oldham Council‘s long-term partnership with a shared ambition to deliver a ‘vibrant, inclusive, and sustainable’ town centre that not only reflects Oldham’s heritage but also meets the needs of the people who live there.
Following ‘extensive consultation’ with the local community earlier this year, where hundreds of people took park and shared valuable feedback to help shape the proposals, a total of 1,619 new homes will be delivered as part of the plans, offering a mix of high-quality, energy-efficient apartments designed for families, older people, and young professionals.
The plans also include social and affordable housing provision too in a bid to help more local people find a home that suits their needs and circumstances.
According to the Council and developers, the approved plans will bring underused sites back into ‘productive’ use and support a ‘cleaner, greener’ future for Oldham, opening the door to new opportunities for local businesses and communities alike.
“This decision marks a key milestone in delivering on our promises for Oldham,” commented Cllr Arooj Shah, who is the Leader of Oldham Council.
Planning permission has been secured to transform Oldham town centre / Credit: Muse Places
“Oldham Council and Muse have a shared, ambitious vision to create a quality place that people genuinely want to spend time in.
“I am thrilled that we can continue moving forward with our plans, delivering high-quality homes, including the provision of social and affordable homes to meet local needs. We will also support local businesses and create opportunities for everyone, as part of a clean, green and sustainable future.
“Together, we are creating a place that we can all be proud of.”
Site investigation works are now complete at the Civic Centre, and works at Prince’s Gate will begin shortly, followed by the former Magistrates’ Court later this year.
With planning consent secured and preparatory works underway, construction at Prince’s Gate is expected to begin this autumn.
The Manc -
2nd December 2021 
