It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Tailgaters and middle lane hoggers warned to change their ‘dangerous’ driving style
Emily Sergeant
A warning has been issued to tailgaters and motorway middle lane hoggers urging them to change their ‘dangerous’ driving style.
Do you find yourself guilty of two of the biggest driving sins from time to time?
Well, according to the latest figures released by National Highways, one in three motorists have admitted to middle lane hogging in their lives, while one in four have committed acts of tailgating on some of the UK’s fastest roads.
These shocking survey findings – which were released back in early March as the Government-owned road management company launched a new campaign – showed that lane hogging was among the behaviours that are most likely to cause motorists and passengers to feel ‘frustrated’, and tailgating was most likely to cause feelings of unease, stress, and anxiety.
Nearly a third (32%) of drivers admitted to lane hogging ‘at least occasionally’ while driving on England’s motorways and major A roads, according to the survey – which polled 2,500 adults between the ages of 16-75.
On top of this, almost seven in ten adults in England (67%) said close following or tailgating is a ‘serious problem’ on these types of roads, but nearly a quarter (23%) admitted to doing it from time to time.
Tut-tut.
Tailgaters and middle lane hoggers have been warned to change their ‘dangerous’ driving style (Credit: IPTC/Ronald Hudson)
It’s these very statistics which have led National Highways to issue an urgent warning that calls on these motorists to “carefully consider” their driving habits, as “little changes can change everything”.
Lane hogging and tailgating both fall under the offence of ‘careless driving’ in England, with the country’s police forces having the power to hand out on-the-spot fines of £100 and three penalty points to those who commit such offences.
“Middle lane hogging and tailgating are far more than mere annoyances for drivers,” warned RAC road safety spokesperson, Rod Dennis, adding that these actions “put everyone on the roads at risk.”
If you’re too close to the vehicle in front, you’re tailgating. This is very dangerous and could lead to a collision. Always leave at least a two-second gap and make sure you follow the advice from The Highway Code.
He continued in his reaction to the release of the latest National Highways figures: “Closely following another motorist could easily result in a serious collision should the driver ahead need to brake sharply for any reason, so the fact nearly one in four drivers admitted to doing so on some of England’s fastest and busiest roads is frightening”.
Mr Dennis said he understands that offenders “might find these habits hard to kick”, but that’s why the urgent calls for motorists to make changes are “so important”.
“By understanding that how we choose to drive affects others, we can each make a real difference to the safety of our roads,” he concluded.
A guide to the brand-new Co-op Live Arena: drinks prices, how to get there, capacity and more
Danny Jones
The brand spanking new Co-op Live Arena finally opens this week and while it might be a touch later than expected, it’s still a huge deal for Manchester and the region as a whole.
While the inaugural pair of shows by British comedy legend Peter Kay might have been postponed due to unexpected power supply problems, that’s exactly what test events are for and Co-Op Live is still due to open its doors to the public later this Saturday as they welcome The Black Keys.
Boasting a jam-packed and ambitious programme already, with shows lined up well into 2025, there’s a lot to take in and as always with new venues, it can be helpful to know all the important details before your first visit – and we’re all in that boat in this case.
But don’t worry, we’ve got you sorted with a whirlwind guide to the Co-op Live.
Everything you need to know about Co-op Live Manchester
Let’s start with why everyone’s getting so excited. Well not only is it going to become the UK’s biggest indoor entertainment venue and one of the biggest in Europe full stop, boasting a maximum capacity of 23,500 people but, like the newly opened Aviva Studios, it’s also set to bring huge revenue into the city.
All told, the total cost of the venue has clocked at approximately £365 million, making it one of the most expensive buildings to ever be erected in the region.
Attracting not only huge artists, comedians and other live acts but now even the likes of the UFC later this year, it really is poised to be an all-purpose entertainment space.
It's official, the @ufc is finally coming back to Manchester! 👊
So who exactly is behind this huge new addition to the city? Well, there are a few big names involved, first and foremost the City Football Group (yes that one – they are neighbours after all).
Man City owner and UAE royal Sheikh Mansour has put forward the lion’s share along with the Oakview Music Group, co-founded by American music mogul and ex-Ticketmaster CEO, Irving Azoff.
Thirdly, another key investor who has played a big role in the marketing for Co-op Live, in case you haven’t already seen him in the promos, is Harry Styles.
Putting in an undisclosed amount into the building as a minority equity shareholder along with Emma Spring, co-director of his record label Erskine Records, Emma Spring, his brand alone is set to help rake in big sums for the venue.
We know that you've been waiting to hear from him…
The former One Direction star speaks ahead of Co-op Live opening to the public.
Those drink prices…
Yep, a lot of you will have surely heard about them already and if you haven’t about Co-op Live’s drinks prices yet, you might want to sit down for this one.
As confirmed by many accounts on social media, the cheapest pints available at the flashy new arena are £8.35 for a Grolsch, with Guinness, Asahi and Salfordian brewers Seven Brothers‘ IPA all setting you back £8.95. Double pints are priced at £16.35 and £17.45.
If you’re looking to save money with bottles or cans, you’ll still be paying around seven quid and wine will cost you £8.95 or £9.25 for 187ml or 200ml servings, respectively. A bottle of vino clocks in at £35 and sprits range anywhere between £9.50 and a whopping £17.40 for a tequila. Yikes.
You’re better off sticking to a soft drink at £4.80 for a pint and that way you can still save money in case you need a bite to eat, as pies are £8.25 and you’ll have to cough up £11.50 if you want a burger. We’ll let you draw your own conclusions on this front, though we’re sure we could make an educated guess.
Seating chart and venue map
Seated for Peter KayStanding and seated for Olivia RodrigoCredit: Ticketmaster
You’ll find the typical arrangement for seated events and standing gigs above but, like most modern event spaces like this, the ‘top-in-class’ venue will likely be able to shuffle into different configurations where needed.
As you can see, there a three main tiers – the ground floor standing area in the lower bowl, level one seating and the upper tier – and there are a total of 32 bars, restaurants and various lounges wrapped into the entire complex.
When it comes to how you get into the arena itself, guests are encouraged to consult their gate (A-G) allocation through their tickets on the dedicated Co-op Live app, which also includes all info regarding shows and the latest announcements from the venue.
Here’s a wider look at the lay of the land:
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A rough guide to getting around Co-op Live (Credit: Supplied)
How to get to Co-op Live, parking and more
Tram
Now, as for how you’ll get to shows at Co-op Live, luckily it’s right next door to a rather famous big blue stadium and its integrated Metrolink stop.
Head along the light blue or orange lines directly to the Etihad Campus or Ashton-under-Lyne and you can get off the tram literally spitting distance from the arena. You can find the full map HERE.
Trams run frequently on the Ashton-Eccles line to the Etihad Campus stop, with services leaving every six minutes from the city centre and until 01:00 on Fridays and Saturdays.
Bus
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If you want to take another new and improved arm of the Bee Network public transport system, not only is there a whole host of routes that drop you off close to the venue but there’ll also be a free shuttle bus from the city centre to and from events between 20 April-30 June 2024.
You can find the full list of bus routes HERE, with the one in closest proximity to the venue being the 53 bus which runs from Cheetham Hill through to Higher Crumpsall, Old Trafford and Pendleton, leaving just a two-minute walk to Co-op Live.
Better still, as part of Manchester City Council and TfGM embracing the new addition to the skyline, they’re also helping cover the costs of people’s journeys when using public transport.
If you’re driving, there is limited parking available at the venue but this must be pre-booked ahead of time. Parking will be released up to 4 weeks before the event and there are designated drop-off areas.
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The postcode is M11 3DU and you can follow the signs towards the wider Etihad Campus as you get closer; directions to the adjacent drop-off points will also be signposted.
Keep in mind that congestion on the roads close to the Etihad Campus is expected to gather around two hours prior to any event, so if you are travelling on the road, these are the suggested times they provide come event day – though estimates will obviously vary:
Alan Turing Way (both directions): plan an additional 20 minutes into any journey by road.
Hyde Road (eastbound): expect an additional 15 minutes to be added to your journey.
Mancunian Way (westbound): plan for an extra 10 minutes of travel time.
There are also three park-and-ride facilities near Co-op Live but be advised that the Velopark and Holt Town stops will be closed post-event to help safely manage crowds:
Ashton West (Ashton line) – 184 spaces and 11 disabled spaces
Ladywell (Ashton-Eccles line) – 332 spaces and 22 disabled spaces
Walk/cycle
Lastly, it’s also just a half-hour stroll from Manchester Piccadilly and you could even walk along the canal all the way to the front door if you fancy taking the scenic route.
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Greater Manchester now also offers the option to hire bikes through the Beryl, with riders able to locate, unlock, get to their destination and then safely lock up the boke all through an easy-to-use app. There are hire points just near the south-west corner of the Etihad Stadium on Ashton New Road.
For more information on all travel options, you can check out the enhanced journey planner.
It's official, the @ufc is finally coming back to Manchester! 👊
While times will obviously change depending on the show, you can expect doors to open around the standard window between 6-7pm.
That being said, the venue is urging visitors to arrive at evening events in the main bowl no later than 9pm. As for curfew, Co-op Live gigs are due to finish by 11pm unless otherwise stated.
Accessibility info
One thing they’re taking very seriously at the Co-op Live is accessibility and after teaming up with disability charity Attitude Is Everything, you can find a full guide to access the arena HERE.
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Having installed lowered service counters, step-free access to all floors, a designated respite room, support for assistance dogs, hearing loops for those with aids/implants, ambulant seating and plenty more, they’ve got it covered so all you have to do is come along and enjoy the show.
And that just about wraps up everything we can think when it comes to what you need to know ahead of Co-op Live’s grand opening at the end of this month.
It’s set to be a world-leading venue and we can’t wait to see it lit up in its full glory when the first acts roll through the doors of big shiny black box this weekend.
Speaking of, once the action is underway, there’ll be a lot of acts coming thick and fast. It’s a new era for Manchester’s live music and entertainment scene.
The Manc -
2nd December 2021 
