It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Heaton Park announces death of its two donkeys following ‘complex’ health and age-related issues
Emily Sergeant
Heaton Park has made the devastating announcement that two more of its beloved donkeys have sadly passed away.
“It is with great sadness that today we announce the passing of Bonnie and Josh, our beloved donkeys, following advice of a vet and The Donkey Sanctuary who visited our Animal Centre,” Heaton Park & Hall announced on its official social platforms at the end of last week.
The death of Bonnie and Josh comes after two of the park’s other donkeys, Ralph and Lenny, also sadly passed away in June and October of last year, respectively.
Both donkeys were born at Heaton Park, and had been steady companions for each other over the last three decades.
Heaton Park announces death of its two donkeys following ‘complex’ health and age-related issues / Credit: Heaton Park & Hall
Josh managed to reach 29, and Bonnie an incredible 33 years of age before passing, and considering that The Donkey Sanctuary says the average life expectancy for a donkey is just over 30, reaching this age was said to be a ‘significant achievement’ for all who cared for Bonnie and Josh.
However in their later years though, both Bonnie and Josh were living with ‘complex’ health and age-related issues.
Ultimately, these complications were what led to them passing away last week.
“They were such kind and gentle souls, and this loss will be felt deeply by all staff, past and present, alongside our visitors,” Heaton Park’s statement continued.
Heaton Park staff closed out their statement thanking everyone who has ever visited the donkeys over the past couple of decades, and particularly the Donkey Welfare Advisers at The Donkey Sanctuary who have supported them and their donkey herd, especially in recent years.
40 people arrested as part of ‘week of action’ to close down active drug lines across Greater Manchester
Emily Sergeant
40 people arrested as part of ‘week of action’ organised last week by police to close down active drug lines across Greater Manchester.
Various policing activities took place alongside partners across all districts and boroughs as part of County Lines Intensification Week – which ran from Monday 2 – Sunday 8 March 2026 – with Greater Manchester Police (GMP) confirming that officers conducted a total of 30 warrants.
Warrants resulted in 40 arrests across Greater Manchester, with 20 active drugs lines closed down, as well as more than £34,000in cash and a substantial amount of class A and class B drugs seized.
Drugs seized included heroin, amphetamines, cocaine, and cannabis.
Mobile phones, weapons – including stun guns, zombie knives, crossbows, and an axe– were also confiscated, and to top it off, electric bikes, designer goods,and high-value electronic deviceswere also recovered during the process too.
40 people arrested as part of a ‘week of action’ to close down active drug lines across Greater Manchester / Credit: GMP
Some of the arrests made include six men, aged between 20 and 42, on suspicion of production of cannabis and abstracting electricity, and three men and one woman were arrested on suspicion of various drug-related offences.
County Lines Intensification Week ran as part of a national coordinated action targeting county lines offenders, removing dangerous drugs and weapons from our streets, and safeguarding vulnerable adults and children, GMP explained.
If you’re unfamiliar, County Lines is the use of dedicated phone lines to deal drugs from one location to another, and it is known for often exploiting children and vulnerable adults who are groomed and coerced into moving, storing, and selling drugs.
County Lines teams use the ‘four Ps’ as a strategy to tackle organised criminals trafficking drugs and safeguard vulnerable people – Prevent, Protect, Prepare, and Pursue.
More than £34,000 in cash was also seized by police / Credit: GMP
Speaking following the week of action, Detective Inspector John Schofield, from GMP’s Serious and Organised Crime Unit. said: “We have had a very busy and successful County Lines Intensification Week, with various lines disrupted thanks to the warrants we have executed.
“Intelligence gathered from the community played a vital role in us being able to conduct this activity, which saw 30 warrants, resulting in 40arrests and 20 drug lines closed down across Greater Manchester.
“This week’s action is a powerful example of our commitment to dismantle organised crime in our region.
Deputy Mayor of Safer and Stronger Communities, Kate Green, added: “County lines activity brings significant harm to our communities. It fuels the supply of dangerous drugs while exploiting children and vulnerable adults who are often groomed, coerced and threatened into criminal activity.
“That is why tackling this type of organised crime is a key priority for partners across Greater Manchester.”
The Manc -
2nd December 2021 
