It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Tickets go live as opening date is announced for Manchester City’s new ‘immersive’ museum experience
Emily Sergeant
Tickets to visit Manchester City’s new ‘immersive’ museum experience have officially gone live ahead of the grand opening.
Set to open in the heart of the £300m Medlock Square entertainment district at Manchester’s Etihad Campus next month, the Manchester City Museum Experience will be spread across 10 distinctive spaces – with visitors invited to take a trip down memory lane with nostalgic environments from throughout the club’s history.
Fans will also be able to take part in interactive media experiences, like posing with all 48 major trophies won by the club’s first teams or trying their hand at football punditry.
The experience will combine the latest immersive technology with physical memorabilia drawn from across the club’s history to do this.
Hidden details and surprising ‘did you know’ facts are set to be embedded across the experience, so that even the most devoted Man City fans will have the chance to discover something new about the club they love.
By combining interactive environments, technology, and authentic artefacts, the experience is aiming to appeal to a wide audience – from lifelong Manchester City supporters, to families and those with a broader interest in football, culture, and the city of Manchester.
“The Museum Experience has been designed as a destination that goes beyond just the pitch,” commented Jeremy Maxton, who is the Director of Visitor Attractions at Manchester City Football Club.
Manchester City releases CGIs and important details of its new ‘immersive’ museum / Credit: Manchester City / Ralph Appelbaum Associates (RAA)
“Whether you’re a lifelong supporter, visiting Manchester for a weekend, or simply looking for a unique day out, we’ve created an experience that offers something for everyone.
“From the recreated environments and original memorabilia to the interactive elements, there are different ways into the Club’s history throughout the Museum.
“We’ve also built in space for new stories to be added over time, so the experience can continue to evolve. It’s been a huge project to bring together and we’re looking forward to people seeing it for themselves later this year.”
The Manchester City Museum Experience officially opens on 14 December, and you can now book tickets to visit from that date here.
Featured Image – Credit: Manchester City / Ralph Appelbaum Associates (RAA)
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TfGM apologises after two weeks of major tram disruption across Greater Manchester
Emily Sergeant
Trams have finally resumed running in Greater Manchester following two weeks of major disruption across the Metrolink network.
Tram services have resumed across the Altrincham, Eccles, and Trafford Park lines this morning (Monday 2 November) following the completion of major track replacement work between Trafford Bar and Deansgate-Castlefield, while maintenance and renewal work also took place on the Eccles line and in the city centre during the planned closure.
Engineers replaced around 4km of track on what is said to be one of the ‘busiest and most complex’ sections of the Metrolink network.
The new track will allow further speed restrictions to be lifted, as according to TfGM, around 100,000 journeys are already benefiting from journey time improvements delivered through previous phases of work every day.
It all forms part of the next phase of the ongoing £150m investment into Greater Manchester’s tram network in a bid to make it ‘safer’ and ‘more resilient and reliable’ for years to come.
✅ This morning, tram services have resumed on the Altrincham, East Didsbury, Eccles, Manchester Airport and Trafford Park lines.
We thank customers for their patience and understanding while these works took place.
↪️ A small service change remains in place through the city centre until the end of service on Wednesday 4 November.
Until then, trams on the Bury – Altrincham, and Victoria – Manchester Airport lines will divert via Exchange Square. Customers may need to change trams to reach Shudehill or Market Street.
👉 Find out more: https://t.co/Vm08ZEDUq4
With services now back up and running, Transport for Greater Manchester (TfGM) has issued a statement apologising for disruption.
Ian Davies, who is the Network Director for Metrolink at TfGM, commented: “This was an essential piece of engineering work on one of the busiest parts of our tram network and will help keep services safe, reliable and fit for the future.
“We’re sorry for the disruption and I’d like to thank passengers, residents, and businesses for their patience while we got on with the job.
“The upgrades mean customers will benefit from smoother journeys and allow us to lift further speed restrictions on this section of the network. It will help speed up our journeys and improve reliability for everyone who uses our network.
“Completing work of this scale on time is a significant achievement and I’d like to thank everyone involved for getting it done safely and efficiently.”
The Manc -
2nd December 2021 
