It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
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Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
News
New cycle lanes and beer gardens closed as Northern Quarter building deemed ‘unsafe’
Daisy Jackson
A section of the new cycleway through the Northern Quarter has been temporarily closed just weeks after opening, after a historic building was deemed to be ‘unsafe’.
Metal fences have now been erected on Thomas Street, blocking part of the cycle lanes and taking over valuable outdoor space for the bars and restaurants along the street.
The building in question stands on the corner of Thomas Street and John Street, once home to the Al Faisal takeaway.
It’s part of a block of 19th century properties in the area that back in 2018 were deemed to be in ”imminent danger of collapse’.
The fencing has been erected around an unsafe building on Thomas Street while scaffolding is built. Credit: The Manc Group
Councillors now say that the Northern Quarter building is unsafe, and will need to be propped up with scaffolding.
The owners of the building want to protect its historic facade but are unable to begin work immediately due to the high construction costs.
But until the scaffolding can be built, temporary fencing has been erected to protect members of the public.
It’s understood that the work will take up to 10 working days to complete.
Several images of the fencing have been circulation on social media, with the NQHQ account tweeting: “If you thought the cycleway through the Northern Quarter was sh*t…..well it just got sh*tter.”
Piccadilly Labour have said: “Building on the corner unfortunately deemed unsafe. Cllr @JonConnorLyons met with the owners who are putting up scaffolding and want to preserve the facade of the building – current construction costs are incredibly high for them to proceed with the development plans this year.”
Councillor Jon-Connor Lyons then added: “Winter weather has made the building vulnerable & cracks have formed which has resulted in the building having to be supported by scaffolding, whilst this happens, these fences have been put up to protect the public. Some reveal in this sort – that is a shame.”
Although the fencing is there in the public’s interest, several local hospitality businesses are concerned about the impact this will have on trade – especially as the fencing has appeared during the heatwave, when punters will be wanting to be outdoors to make the most of the sunny weather.
The Smithfield Social, which is part-owned by the Courteeners’ Liam Fray, has lost a chunk of its outdoor seating – though it does still have space for tables on Edge Street.
A spokesperson for the bar said: “The building works which commenced yesterday have impacted our outside trade significantly.
“We usually have eight tables out the front but after lengthy talks with councils and licensing we have come up with a solution which means we now have a severely reduced area with only four tables.
“The area seems to be an after thought as we are the only business affected by it. Fierce have moved their area but they do not lose any space.
“I have no doubt that we have lost significant patronage because of this, as who wants to sit outside with heavy machinery next to you and dust being blown in your face? Quite unfortunate timing with the great weather we are forecast to have over the coming days.”
The Manc has approached Manchester City Council for comment.
Featured image: The Manc Group
News
New stations appear across Manchester for city’s rentable ‘Burnham bike’ scheme
Daisy Jackson
The roll-out of Greater Manchester’s Bee Bike cycle hire scheme has stepped up a gear, with new docking stations appearing across the city centre.
The scheme, nicknamed the ‘Burnham bikes’ as a nod to London’s ‘Boris bikes’, initially launched in Salford and along the Oxford Road corridor.
Several new yellow stations have appeared around Manchester now, with plenty more on the way.
The next phase of the roll-out of the Bee Bikes has seen stations installed around St Peter’s Square and Manchester Central.
‘Burnham Bike’ cycle hire stations near St Peter’s Square. Credit: The Manc Group
By the time the scheme is complete, bike numbers will increase to 1,500, which will include 300 e-bikes.
It’s all part of the vision for a Bee Network – a joined-up, integrated public transport network across the region.
And it’s certainly off to a more successful start than Mobike, which famously withdrew from Manchester due to high levels of vandalism and theft.
The Bee Bikes are funded by TgGM and operated by Beryl, which runs similar schemes in London, Watford and Bournemouth.
Here you go – your new “Bee Bikes” which will be on our streets from November. 👇🏻
Many will be e-bikes and, in time, part of a single integrated payment system across bikes, buses and trams.
Richard Nickson, programme director, Cycling and Walking at Transport for Greater Manchester, said: “The cycle hire scheme has really taken off in Greater Manchester since it was first introduced, and we are seeing significant numbers of riders and distances travelled by on the bikes- which is fantastic, particularly as we are still in the early days of the scheme’s roll out.
“The next phase of the roll-out has now started in Manchester city centre, with new stations installed at key locations including Manchester Central Library, Manchester Central Convention Centre and St Peter’s Square.
“More stations are due to be installed in Manchester city centre over the coming weeks, before the scheme continues to expand its footprint to new locations in Salford and Trafford.
“Once complete the scheme will see bike numbers increase to 1,500 – including 300 e-bikes – and over 150 new stations in operation.”
The Manc -
2nd December 2021 
