It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Greater Manchester’s heritage railway issues statement as it’s forced to cancel services this week
Emily Sergeant
Greater Manchester’s iconic heritage railway has been forced to cancel its services this weekend due to the heatwave.
In case you hadn’t heard, Amber Extreme Heat warnings and heat-health alerts have been issued by the Met Office and the UK Health Security Agency (UKHSA) through to Thursday this week – with temperatures widely exceeding 35°C nationwide, and in some areas – particularly on the south coast – potentially even reaching 38°C.
Heatwave conditions in the UK are met when a location records a period of at least three consecutive days with temperature values meeting or exceeding the heatwave temperature threshold for that location.
It does seem, however, that northern parts of the country – especially the North West – are missing most of the extremely hot conditions.
Current forecasts indicate that the peak temperatures for Greater Manchester this week will be tomorrow and Thursday, with highs of 33°C in the city centre.
Despite not reaching the heights of the south, East Lancashire Railway (ELR) has still had to act in advance and has taken the decision to cancel its scheduled services for the next two days as the forecast is ‘too severe’.
Taking to social media to share its decision today, ELR wrote: “Due to the current weather warning for the UK, the decision has been taken to cancel all services on Wednesday 24th and Thursday 25th June 2026, including the afternoon tea and mid-week luncheon dining experiences.
“The welfare of both staff and customers is paramount to the ELR, and we believe that the risk in the extreme heat that has been forecast is too severe to allow for the running of our ordinary services.”
As things stand, ELR says its current plan is to have services resume with the evening dining train on Friday 26 June, but this will still be ‘subject to review’, and further updates on this will be issued later in the week.
Visitors who have already pre-booked services over the two cancelled days will be contacted via email to have their options explained to them.
“We apologise for any inconvenience,” ELR closed out its statement.
Featured Image – ELR
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TfGM issues safety warning and advice for travelling on public transport during extreme heat wave – including ‘get off’
Daisy Jackson
Transport for Greater Manchester has urged passengers to ‘stay safe’ when travelling as the city braces for an extreme heatwave this week.
As well as issuing some safety advice, TfGM has also warning that delays and disruption are possible across the network as temperatures climb as high as 36ºC on Wednesday and Thursday this week.
Customers are being advised to carry water with them when travelling, and to wear light clothing.
Also included in the travel advice is to ‘get off’ public transport at the next stop if you feel unwell, to seek fresh air.
It’s also advised to allow more time for your journey and to check the latest information and advice before setting off.
And most importantly, passengers are asked to look out for each other, especially those who are vulnerable.
The Bee Network may experience disruption later this week as the overhead lines that power the trams and trains are often adversely affected by high temperatures.
TfGM’s Customer and Growth Director, Fran Wilkinson, said: “Very high temperatures are forecast this week that can affect both people and the transport network.
“We will have staff out to help those who need it, and I would encourage customers to take a few simple steps to stay safe and comfortable while travelling, such as by carrying water, travelling at cooler times of the day and looking out for others.
“Due to the heat, there may be some disruption to Bee Network or local train services and I would encourage people to check for the latest information and advice before making their journey.”
TfGM advice for travelling in heatwave
Carry water and drink plenty of fluids
Avoid travelling during the hottest part of the day where possible
Wear light clothing and stay in the shade
If you feel unwell while travelling, get off at the next stop and seek fresh air
Plan your journey, check for the latest information and advice before setting off and allow extra time to make your journey
Look out for other passengers who may need help, especially those who are more vulnerable
Bee Network staff will be out across the network to help passengers, who can get the latest travel information and advice by checking the website or app.
The Manc -
2nd December 2021 
