It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
News
Council announces return of FREE firework displays in Manchester parks
Emily Sergeant
The skies over Manchester will light up once again, as free firework displays are set to return to several of the city’s parks.
You may remember that major fireworks events throughout the city had been paused following the COVID-19 pandemic, due to funding challenges, with Manchester City Council choosing to invest in a range of other community-focused events across throughout the autumn season instead, rather than one-off firework celebrations.
But now, once this November rolls around, all of that is set to change.
That’s because, on Saturday 7 November, free fireworks events will return to Heaton Park, Wythenshawe Park, and Platt Fields Park.
First up, there will be a reduced-noise, low-impact display at 5pm for families and SEND audiences, and a main fireworks display then to follow a little later at 8pm.
The Council has announced the return of free firework displays in Manchester parks / Credit: Unsplash
Each of the three parks will host lantern making workshops in the weeks leading up to the events too, with family-friendly lantern parades taking place ahead of the 8pm firework shows.
The Council says that the return of the free fireworks events reflects residents’ recent feedback about what they want to see in their community and how they want funding to be distributed.
“It’s a chance, at the start of the shorter days and beginning of the dark winter months, to come together and resume a much-loved annual tradition as well as enjoying an evening of safe entertainment and spectacular fireworks displays,” Manchester City Council said in a statement.
Councillor Basat Sheikh, who is the Executive Member for Neighbourhoods, added: “We are delighted to announce and welcome the return of our much-loved fireworks celebrations.
It’s the first time they’ve returned since the COVID-19 pandemic / Credit: Elisha Terada (via Unsplash)
“Our parks should be shared spaces that create opportunities for Manchester people to gather, which is why bringing back the fireworks displays was top of our agenda. And we also recognise the importance of community which is why we will also continue to invest in a wide range of activities in our parks throughout the year.
“The return of these events is a wonderful opportunity for families and communities to create lasting memories and enjoy the long-standing tradition of fireworks in our parks in a safe way.”
Additional entertainment will be announced for each park in the coming weeks too, so keep your eyes peeled for more.
Featured Image – Alex Jones (via Unsplash)
News
Stockport man admits to drugging and raping his wife without her knowledge for more than 20 years
Emily Sergeant
A man in his 60s from Stockport has admitted drugging and raping his wife in a ‘horrific’ 20-year campaign of abuse.
According to Greater Manchester Police (GMP), the man – who cannot be identified in order to protect the life-long anonymity of the victim – previously admitted five counts of rape, three counts of sexual assault, six counts of assault by penetration, and one count of sharing intimate photos or film.
And now, during an appearance at Manchester Minshull Street Crown Court yesterday (14 September), he pleaded guilty to a further 45 charges.
This makes it 60 charges in total the man has now pleaded guilty to.
Some of the charges he pleaded guilty to yesterday include a further 16 counts of rape, nine counts of assault by penetration, seven counts of sexual assault, and four counts of attempted rape, amongst several others.
Speaking following the court appearance yesterday, GMP’s Assistant Chief Constable, Rick Jackson, said: “Our focus remains on supporting the victim of this horrific campaign of abuse through what is a very complex investigation.
“Specialist support continues to be provided to the victim at the centre of this case.
“If you are concerned you or someone you know may be affected by drug-facilitated sexual abuse, please know that you do not need proof, certainty, or a clear memory to be taken seriously.
“You are not expected to understand exactly what has happened or who was involved in order to be taken seriously. If you feel that something has happened, then please report it or ask for help.”
GMP reiterates that anyone who does choose to report sexual abuse does not need a full account or clear memory, can share as much or as little as they feel able, and will be supported by trained officers, as their ‘immediate’ safety and wellbeing will be the ‘priority’.
They may also speak to a support organisation first and decide later whether to involve police.
Saint Mary’s Sexual Assault Referral Centre – Services are available on a 24-hour basis, and can be accessed by calling 0161 276 6515.
Greater Manchester Rape Crisis – Call on 0161 273 4500 or email [email protected]
The Manc -
2nd December 2021 
