NHS rolls out new ‘life-extending’ ovarian cancer drug for first time in 20 years
Female patient in a hospital bed / Credit: Stephen Andrews (via Unsplash)
The NHS has approved a new ovarian cancer treatment for the first time in two decades.
From today, hundreds of women with ‘hard-to-treat’ ovarian cancer could benefit from a new life-extending drug on the NHS called mirvetuximab soravtansine, and it will be offered to patients living with whose disease has unfortunately stopped responding to standard chemotherapy treatments, providing them with new hope of extra time to live.
The rollout of the drug on the NHS follows a major global clinical trial involving eight NHS hospitals, which showed that the treatment delayed cancer progression and prolonged survival – with patients living 16.5 months on average compared to 12.8 months with chemotherapy.
One patient said the treatment enabled her to get on with life ‘rather than spending it in bed recovering from the side effects of chemotherapy’.
So, how does it work then?
Well, the drug combines a ‘homing’ antibody with a cancer-killing medicine – often described by scientists as a ‘biological missile’ or ‘trojan horse’ therapy – and it works by attaching to ovarian cancer cells that have a protein called folate receptor alpha (FRα) on their surface, before releasing a cancer-killing molecule which destroys the cell from within.
The treatment is given intravenously, via a drip, over two to four hours, once every three weeks.
The drug may also have ‘more tolerable’ side effects than traditional chemotherapy, with the treatment aimed more precisely at cancer cells than chemotherapy.
The NHS estimates up to 400 patients in England each year could benefit.
“This represents the most significant breakthrough in NHS treatment for these hard-to-treat ovarian cancers in over two decades, commented Professor Ruth Plummer, who is the NHS’s national clinical lead for cancer drugs.
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“We’re delighted it will now offer hundreds of women much-needed hope of precious extra time with their loved ones.
“It is part of a growing wave of more targeted cancer therapies which, by homing in on specific features of cancer cells, are helping us improve patients’ lives.”
Featured Image – Stephen Andrews (via Unsplash)