News

Young people who’ve had COVID to be offered £5,000 for being deliberately re-exposed to the virus

The Manc The Manc - 19th April 2021

Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.

It’s all part of a new study that aims to monitor how their immune systems react.

The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.

The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.

So, what does the study entail then?

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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.

Once the trail is complete, participants will then receive just under £5,000 as payment.

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The study will take phase in two phases.

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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.

Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.

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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.

“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.

“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.

The trial is expected to start in the summer.

Featured Image – Wikimedia Commons

News

Manchester palaeontologist unearths bones of what may be the largest known marine reptile

Emily Sergeant Emily Sergeant

A Manchester-based palaeontologist has unearthed the bones of what may be the largest known marine reptile.

This new identification is a crucial part of a fascinating eight-year long discovery journey.

It all started when a seasoned fossil collector named Paul de la Salle found a giant jawbone on Lilstock Beach, near Bridgewater in Somerset, back in May 2016, and then father and daughter, Justin and Ruby Reynolds from Devon, found the first pieces of a second jawbone and another giant bone while searching for fossils on the beach at Blue Anchor, also in Somerset, in May 2020.

And now, a palaeontologist at the University of Manchester (UoM) Dr Dean Lomax, has identified the fossilised remains of the second gigantic jawbone that measures more than two metres long.

Experts have identified these bones as belonging to the jaws of a new species of enormous ichthyosaur – which is a type of prehistoric marine reptile – and astonishing estimations suggest the oceanic titan would have been more than 25-metres long.

Dr Lomax has been working together with Justin and Ruby Reynolds, along with Paul de la Salle and several family members, since the father-daughter duo first contacted them about their groundbreaking discovery in 2020.

A Manchester palaeontologist has unearthed bones of what may be the largest known marine reptile / Credit: UoM

“I was amazed by Justin and Ruby’s find,” Dr Lomax commented.

“In 2018, my team and Paul de la Salle studied and described Paul’s giant jawbone, and we had hoped that one day another would come to light.”

He explained that Justin and Ruby’s new specimen was “more complete and better preserved” than the first find, and that he “became very excited” at the chance to learn more following their discovery.

As mentioned, the Manchester-based research team, led by Dr Lomax, revealed that the jaw bones belong to a new species of giant ichthyosaur that would’ve been about the size of a blue whale, and they have called the new genus and species Ichthyotitan severnensis – which means ‘giant fish lizard of the Severn’.

The bones – which represent the very last of their kind – are around 202 million years old, and date back to the end of the Triassic Period in a time known as the Rhaetian.

During this time, the gigantic ichthyosaurs swam the seas while the dinosaurs walked on land.

The University of Manchester, where Dr Dean Lomax works as a palaeontologist / Credit: UoM

Ichthyotitan is not the world’s first giant ichthyosaur, but the discoveries by Paul, and Justin and Ruby, are said to be “unique among those known to science”, as they appear roughly 13 million years after their latest geologic relatives – including Shonisaurus sikanniensis from British Columbia in Canada, and Himalayasaurus tibetensis from Tibet in China.

Speaking on the confirmation of the bones’ identification this week, Dr Lomax said: “This research has been ongoing for almost eight years.

“It is quite remarkable to think that gigantic, blue whale-sized ichthyosaurs were swimming in the oceans around what was the UK during the Triassic Period.

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“These jawbones provide tantalising evidence that perhaps one day a complete skull or skeleton of one of these giants might be found.”

Featured Image – UoM

News

Northern Quarter favourite Pie and Ale has sadly closed down

Danny Jones Danny Jones Pie and Ale Manchester closed down

Beloved Northern Quarter eatery and pub Pie and Ale has sadly and quietly closed its doors this week in yet another gutting bit of news for the Manc hospitality sector.

Known for its legendary homemade pies, great selections of ales, craft beers and lagers, not to mention a great little pub when it comes to watching live sport, it’s long been considered an NQ institution.

Unfortunately, however, as confirmed by a sign posted in the window, Pie and Ale has now closed for business after more than a decade.

Safe to say, we’re absolutely gutted, as we’re sure everyone else is.

Credit: The Manc Eats

While no official announcement has been made on their social media as yet, which will no doubt receive love and sadness from its loyal following, the sign in the window simply reads: “Pie and Ale has unfortunately ceased trading. Apologies for any inconvenience.”

The local favourite which was always hailed for being great value for money – celebrated especially for its popular pie and a pint for under a tenner deal – also served up great nibbles and light bites as well as dessert specials.

Although the Lever Street spot previously shut down for a short spell back in 2018 due to what they labelled as “unforeseen circumstances” before reopening just two months later, this latest update looks pretty definitive.

Sister-site Bakerie also ceased trading back in April 2019, with husband and wife founders, Alyson Doocey and David Cook, admitting that all independents had been “feeling the squeeze”.

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While we have few other details at this stage, it does look like Pie and Ale has indeed closed down for the foreseeable future.

A mainstay on our list of the best pies in Manchester since day dot and just the latest in the list of losses in 2024 so far, they will be sorely missed.

We sincerely hope this is like last time and will keep our fingers crossed that we see the pie pros and expert pourers back in business at some point.

RIP to an NQ icon.

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Featured Images — The Manc Group

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