Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
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Traders to move out of Manchester food hall as it pivots to ‘new chapter’
Daisy Jackson
Manchester food hall New Century will be closing its kitchens, it has announced, making way for a ‘new chapter’.
The New Century Kitchens are home to some top local food traders, including Parmogeddon’s Fricken concept, Wholesome Junkies, and Ply Pizza.
The food hall opened in 2022 as part of the iconic music venue’s rebirth, creating a modern mid-century space with six kitchens.
In the years since, it’s welcomed a rotation of amazing food offerings, including Hip Hop Chip Shop, Banh Vi, and Zumuku Sushi.
Now, New Century Kitchens has announced it will be ‘evolving’ to make live events part of the offering across the venue – not just upstairs in the main gig space.
That means that the traders currently based here will be moving out, though the venue has assured people that they have been supported as they take their next steps.
New Century said that music is in the building’s ‘DNA’ and this chapter will reflect that.
New Century Kitchens will close, with traders moving outNew Century is entering a ‘new chapter’
In a statement shared with The Manc, they said: “The ground floor at New Century is evolving. We are currently finalising plans for live events to become an even bigger part of our offering across the whole of the venue.
“As part of this evolution the current community of independent traders are moving onto exciting new chapters, and we have been working very closely with them to support all of these brilliant businesses in their next steps.
“Music is in the DNA of our iconic building and this new chapter will reflect that.
“New Century is a place for people to come together through entertainment and good hospitality and we’re looking forward to sharing more details soon.”
Police urgently appeal for footage after fatal stabbing in Moss Side
Emily Sergeant
Police have issued an urgent appeal for footage in their ongoing investigation into a fatal stabbing in Moss Side last week.
Detectives from Greater Manchester Police (GMP) are appealing for information – and in particular, mobile phone footage – as they continue to investigate the murder of 34-year-old father of three, Adrian Brown, who died following a stabbing in Moss Side last Friday (8 May).
Police were called to Raby Street in Moss Side at around 11pm last Friday to reports of a serious assault.
Mr Brown was found with stab wounds to the chest, and was rushed to hospital, but despite the best efforts of medical staff, he sadly died from his injuries.
An 18‑year‑old man was arrested on suspicion of murder the following day (Saturday 9 May) and remains in custody. A second man, aged 26, has also been arrested on suspicion of murder, while two men, aged 25 and 38, and a 26‑year‑old woman have been arrested on suspicion of assisting an offender.
With the police investigation now progressing at pace, officers are keen to hear from anyone who may have captured mobile phone footage at any point during the evening – particularly in or around the West Indian Sports and Social Club on Westwood Street.
Adrian had been attending an event at the club that evening, before at around 11pm, he was assaulted just outside the front entrance.
“There were around 200 people at the club that night, and we believe some of those present may have information that could help us understand what happened,” commented Detective Inspector Alex Wilkinson.
“This could include eyewitness accounts, or photos and videos taken throughout the evening.
“I appreciate that speaking to police can feel daunting, but anyone with footage can upload it anonymously through our dedicated Major Incident Public Portal.”
Anyone with information or footage that may assist the investigation is asked to contact GMP on 0161 856 2270 or 101, quoting log 4069 of 08/05/26, or uploading to the MIPP online here.
Alternatively, information can be passed on anonymously via Crimestoppers on 0800 555 111.
The Manc -
19th April 2021 
