Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
News
Major headliner pulls out of Manchester Village Pride
Daisy Jackson
One of the Manchester Village Pride headliners has had to pull out of their scheduled appearance, just one day before the celebrations begin.
Nadine Coyle was supposed to be headlining the LGBTQ+ event on Friday 27 August.
But in a statement shared by Manchester Village Pride today, they announced that the former Girls Aloud star is ‘under the weather’.
Nadine will be pulling out of her headline slot to ‘rest and recuperate’, but added that she hopes to see Manchester for Pride again soon.
Thankfully, Manchester Village Pride has already found a suitably fabulous replacement for the main stage on Friday – B*Witched.
The iconic Irish girl group will be encouraging ticket-holders to dig out their double denim and dance to hits like C’est La Vie and Rollercoaster.
In the statement shared by Manchester Village Pride, Nadine’s team said: “Nadine is so sorry to have to step out of Manchester Village Pride this year. It was her very first Pride many years ago and she loves getting to spend time with you all.
“Nadine’s voice has been under the weather and she only wants to give absolute best to you all which sadly won’t be possible this weekend as she needs time to rest and recuperate.
“We hate to do it so near the day. Nadine was really hoping she was going to be well enough and hopes she can see you in Manchester for Pride again soon.
“Thank you for being so kind and understanding and we hope you have a wonderful weekend.”
Manchester Village Pride added: “We know how excited many of you were for a massive hit of 2000s pop nostalgia, and we promised you a party. We’ve been working around the clock, and we are beyond thrilled to announce that pop royalty B*WITCHED are stepping in at the eleventh hour!”
Chester Zoo announces return of its £10 tickets for limited time only with extended opening hours
Emily Sergeant
Chester Zoo has announced the return of its popular £10 tickets deal for a limited time only.
You may remember that earlier this summer, Chester Zoo invited people from across the North West to visit for just £10, and as the offer proved so popular, they’ve now brought it back again for a limited time.
For the past three years running now, Chester Zoo has officially been named the UK’s best zoo thanks to tens of thousands of positive TripAdvisor reviews, and now as the summer draws to a close, you’ll get to see exactly what makes it such a special place worth visiting for a cut price.
With the offer only applicable to afternoons this summer, Afternoon Tickets allow entry to Chester Zoo from 2pm onwards – with the last entry being one-hour before it closes.
Chester Zoo is offering £10 tickets to visitors this summer / Credit: Chester Zoo
Without this offer, standard admission tickets to Chester Zoo usually cost up to £38 for adults, £37 for students, and £28 for children, all including a 10% donation to the zoo’s conservation efforts, while babies and carers go free.
So it really is worth making the most of these limited-time £10 tickets while you still can – with the offer now running until 6 September.
The best bit about the offer returning? The zoo is currently operating its extended opening hours until 6pm too, so included for the bargain price of a £10 ticket, you’ll even get to see all the animals while the sun goes down.
Afternoon tickets are only available online and must be booked in advance to claim the £10 offer.
Tickets can only be purchased online before 4pm on the day of your visit, and standard admission tickets can be purchased from our ticket office at the main entrance.
Find out more and book your £10 tickets online here.
The Manc -
19th April 2021 
