Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
News
UK Government announces £100 fines for ‘antisocial behaviour’ on public transport
Emily Sergeant
The Government has today announced plans to tackle antisocial behaviour on public transport.
In a bid to crackdown on loud music, littering, vaping, and other threatening behaviour on buses and trains, guidance was issued by the Government today for local authorities to prosecute and even issue fines of up to £100.
For many, playing audio out loud on public transport – also known as ‘loudcasting’ – has become one of modern life’s most irritating parts of the daily commute, but now, a new national campaign is aiming to encourage rail passengers, in particular, to ‘share the carriage, not the noise’ to improve the journey experience for all.
This will include reminders of the rules in place on the rail network and, if a passenger refuses to stop when asked by authorised rail staff, they can be removed from the train at the next station or face fines up to £1,000.
On buses, however, the powers for authorities were already made possible by the Bus Services Act 2025, meaning all local transport authorities in England are able to set and enforce their own rules.
Authorised officers – including transport safety officers and the police – will be responsible for enforcement, rather than bus drivers themselves, and they will be tasked with a three-step approach to deal with incidents. They will need to:
Engage with the person
Explain the rules and their impact on other passengers
Take enforcement action if they refuse to comply
“We’ve all been on the train when someone starts blasting music or videos from their phone,” commented Prime Minister Andy Burnham.
“It gets on your nerves and can quickly spoil the journey, so we’re launching a nationwide campaign reminding passengers to use headphones on trains. On top of that, we’re giving local leaders new powers to tackle loud music, vaping and littering on buses.
“It’s a simple thing, but one that will make journeys that little bit better for all of us.”
Ben Plowden, Chief Executive at the Campaign for Better Transport, added: “Antisocial behaviour is not just irritating, it can be a real deterrent to people using public transport – especially people with different accessibility requirements.
“If these new powers are properly and visibly enforced, they should help everyone feel safe and comfortable on public transport and enjoy the ride.”
Featured Image – Northern
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Police provide update after stabbing of 14-year-old boy at Manchester Arndale carpark
Emily Sergeant
Police have provided an update following the stabbing of a young boy in Manchester city centre over the weekend.
At around 3:15pm this past Saturday afternoon (17 October 2026), officers from Greater Manchester Police (GMP) were called out to reports of a stabbing on the ninth floor of the Arndale carpark in Manchester city centre.
Emergency services attended the scene, and a 14-year-old boy was taken to hospital with injuries consistent with a stab wound.
Thankfully, the victim’s injuries are not believed to be life-threatening or life changing, but an investigation and enquiries are ongoing.
Detective Inspector Sam Jones, of GMP’s City of Manchester District CID, said this will ‘understandably’ cause concern, but has assured the public that police believe this to be an ‘isolated incident.
“Detectives at the scene are working extremely hard to process the scene with Crime Scene Investigators,” explained DI Jones in an update statement issued.
“The car park is expected to be closed for several hours, so we ask for your understanding and patience whilst we gather evidence to bring these offenders to justice.
“Detectives and Officers will be in the area today to speak with local businesses and members of the public to provide reassurance. This is believed to be an isolated incident with no risk to the wider public.
“Greater Manchester Police are committed to diligently investigating all knife crime and bringing offenders to justice, and we are asking for anyone with information about this incident to come forward to assist with our enquiries.”
Anyone with information is asked to contact police on 101, quoting log 2050 of 17/10/2026, or via the LiveChat function. Alternatively, contact Crimestoppers anonymously on 0800 555 111.
The Manc -
19th April 2021 
