Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
News
Manchester’s iconic Vimto statue to be removed for repair – with Aitch-sponsored sculpture in its place
Daisy Jackson
One of the city’s most familiar landmarks will soon be leaving its spot in town, as the iconic Vimto statue is removed.
The sculpture has been in Vimto Park off Sackville Street since 1992, and consists of a giant Vimto bottle surrounded by oversized fruit.
But the art piece dedicated to Manchester’s most famous drink has weathered (it’s made of wood, after all) and will have to be dismantled in the coming months for an undisclosed period of time.
This will be the second time the Vimto statue has undergone maintenance work, having last received a colourful paint job in 2011.
Worry not, though, Manchester – a new sculpture, dedicated to another local drinks brand, is already in the works until our beloved Vimto statue returns.
Local rapper Aitch, who launched his own drinks brand SYPS last year, has decided to make good use of the space.
A gigantic statue of a SYPS can is to be installed later this year in place of the Vimto statue, created by a local artist.
I don’t know why any of you are surprised – there haven’t been many product launches or marketing opportunities that Aitch hasn’t jumped on this year.
Rave in the Super Awesome Deluxe burger takeaway? Done it.
‘Launching’ Joe & The Juice back into Manchester? Done that too.
Performing on a train to launch a limited-edition Southern Comfort called ‘Northern Comfort’? Yes, that also happened.
Aitch is funding a temporary SYPS statue in place of the Vimto statue in Manchester
He’s now announced that he’ll be funding a new statue for the city centre while our beloved Vimto statue is gone.
A spokesperson for Manchester City Council said: “While it’s a shame to see our beloved Vimto statue leave the city centre, it’s important that this landmark is preserved for the future before it’s too late.
“When Aitch kindly offered to fill the space in Vimto Park with a SYPS sculpture, how could we say no?”
Aitch said in a statement: “I couldn’t leave my Manny without a drinks statue, could I? Also happy April Fool’s day you idiots.”
The funds will help improve the already incredible music scene in Manchester, benefitting staples likes Night and Day Café, Matt and Phred’s Jazz Club, SOUP and more.
All of the donations will be distributed across six independent music venues and will be used for various instruments, PA equipment, backline technology and other necessities depending on the requirements of each site.
Elbow have teamed up with Co-op Live in aid of supporting Manchester grassroots venues.Credit: Supplied
This initiative has been keeping Manchester’s Northern Quarter in the forefront of people’s minds when it comes to live music as well as the impressive Co-op Live.
Alongside providing vital resources for these local institutions, Elbow teaming up with Co-op Live also helps cement the North West as one of the main powerhouses in relation to live music.
The latest efforts from the largest indoor arena in Manchester fall in line with celebrating one year of bringing some of the best live music to the city, being officially open for 12 months in May.
Co-op Live have made a commitment to the people and the planet, promising to donate £1 million annually to the Co-op Foundation.
The stunning Co-op Live venue, Manchester’s largest indoor arena.Elbow performing at Co-op Live, marking history as the first act to grace the venue.Credit: Audio North/Supplied
Manchester’s latest live music venue also contributed significantly to selected charities, including Happy Doggo – chosen by Liam Gallagher and Eric Clapton’s addiction recovery centre, Crossroads.
As Elbow teams up with Co-op Live, even more money is making its way to necessary resources, this time in the likes of crucial live music establishments.
Elbow front-person Guy Garvey says: “Playing Co-op Live’s opening night will stay with us for a lifetime, not least because of how incredible the room sounded.”
“When the venue donated funds in our name to support the city we love, it made complete sense to carry that through to the Northern Quarter and to venues that have meant so much to my bandmates and I throughout our career.”
Guy Dunstan, Senior Vice President and General Manager, Co-op Live, adds: “In the past year, I have been proud to see Co-op Live become an integral part of such an incredible city.”
“Teaming up with Elbow to directly support the venues that first put Manchester on the map, and to share something so intrinsic to us as venues – proper sound – is something truly special.”
The Manc -
19th April 2021 
