Bronx Zoo has reported that one of their tigers has tested positive for COVID-19 - with fears that several other big cats may also have contracted the illness.
The four-year-old Malayan tiger, Nadia, is assumed to be the first animal of her kind to become infected with COVID-19.
It is suspected that a zookeeper, who was not showing any symptoms, may have passed on the disease.
Nadia began showing symptoms - including a dry cough - in March, and a number of lions at the zoo have also been showing symptoms.
All animals are expected to recover.
The US Department of Agriculture confirmed Nadia's test result at its veterinary lab - marking the first positive case of COVID-19 in an animal in the United States.
There have been reports of domestic cats and dogs catching the disease, which could be due to close proximity with owners.
Research into animal transmission of COVID-19, however, is still in its infancy.
The World Organisation for Animal Health has confirmed studies are underway to in a bid to improve understanding of animal coronavirus cases.
Guidelines suggest that anyone with COVID-19 symptoms should limit contact with pets to prevent them contracting the virus.