It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Salford confirms another ex-player as new CEO of phoenix rugby club
Danny Jones
As Salford turns the page of a new chapter in its rugby league history, ex-Red Devils player Ryan Brierley has been announced as the new chief executive officer (CEO).
His appointment was confirmed on Wednesday, 24 December, giving Salford rugby fans some fresh hope over the festive period.
Brierley, who played as a full back at Salford Red Devils from 2022 before leaving for Oldham RLFC halfway through last season earlier this year, follows fellow former player Mason Caton-Brown in returning to the team in a leadership capacity.
Sharing the news on his own social media, he wrote: “Incredibly honoured to announce I have been appointed Chief Executive Officer of Salford RLFC.”
His official statement goes on to read: “I would like to place on record my gratitude to the board members Malcolm Crompton, Mason Caton Brown and Paul Hancock for this opportunity. I would also like to thank the RFL and Salford City Council for their continued support.
“Lastly, but most importantly, to the Salford fans: what we had to go through last year was heartbreaking. I think I can speak to the wider Rugby League community and echo the sentiments of all fans that no club should ever go through that experience.
“Thank you for letting me lead this organisation into a new era. I’ve always said Salford people are my people and I will protect this club, with its best interests at heart. It is important [that] expectations are managed, and patience is required.”
He signed off by simply asking for the same support he was afforded as a fan, adding: “I have no doubt in my mind that you will go above and beyond, it’s just what Salford fans do…”
Led by the aforementioned Caton-Brown (a retired winger who played for the Red Devils between 2014-26), as well as another pair of directors in Hancock and Crompton, the Salford phoenix club has officially been given a Championship license for 2026.
Although relegation from the Super League and liquidation after 152 years were dark days for the club, this new consortium has already provided fans with some promising signs.
Besides saving the Salford sporting institution from total extinction, having previous members of the old outfit who know the bones, the stadium, the culture and the city so well is obviously a big bonus.
For now, it is a race against time to get a squad ready for the season opener against Brierley’s last team, Oldham – though contracts for a head coach and several players have reportedly been “pre-agreed”.
Featured Images — John Moorhouse (via Geograph)/supplied (via Rumpus PR)
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Netflix drops the first trailer for upcoming Peaky Blinders film
Danny Jones
It looks like Christmas has come early for TV drama fans and cinephiles, because Netflix has officially dropped the first trailer for the upcoming Peaky Blinders movie.
Popcorn at the ready – even the teaser alone has got us fired up.
ln just 70 seconds, they’ve managed to pull us right back in, and we cannot wait to see Cillian Murphy back in full-on Tommy Shelby mode.
Not exaggerating when we say we have LITERAL chills.
As you can see, they certainly haven’t scrimped on the budget with the first-ever feature-length Peaky Blinders film, neither in terms of production value nor the cast.
Then again, having already hosted the likes of Sam Neill, Tom Hardy, Adrien Brody, Anya Taylor-Joy and others in the series itself, as well as going on to become one of the most successful BBC shows of all time, they were never going to.
We’re sure you spotted plenty of them for yourselves, but the debut trailer for The Immortal Man gives us not only our first glimpses of now Oscar-winning Murphy, 49, back in the saddle (both figuratively and literally) but also fellow blockbuster Irish actor, Barry Keoghan.
Other big names set to appear in the movie – set for a limited release in theatres before launching exclusively on Netflix – include Rebecca Ferguson and Tim Roth. It still remains unclear, however, as to how any of these characters will knit into the new season.
It’s also worth noting that the trailer shares a little snippet of the historical context, this continuation of the Shelby story is playing into, as we see what looks to be Nazi figures meeting on screen.
Creator Steven Knight has already confirmed that the plot will fast-forward some years to meet back up with Tommy at the outset of WWII and his ancestral home of Birmingham during the Blitz.
Having already confirmed 6 March as the theatrical release date ahead of it going live on Netflix a fortnight later, the anticipation was seriously starting to ramp; this latest look has only added to the tinderbox of excitement.
What do you make of the Peaky Blinders: The Immortal Man trailer, and will you be watching it?
The Manc -
2nd December 2021 
