It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Two Trafford towns are set to see dozens of new EV charging points installed imminently
Danny Jones
Two big towns on the border of Greater Manchester and Cheshire are set to see a fresh batch of electric vehicle (EV) charging points installed throughout their streets by Trafford Council very soon.
Local authorities have teamed up with engineering and infrastructure company Amey to roll out a series of new EV charging stations across Trafford, starting with Altrincham and Hale.
Dating all the way back to 2020, the collaboration with Transport for Greater Manchester (TfGM), the brand was tasked with helping improve sustainable travel across the area as the government body’s electric vehicle charging suppliers.
Steady improvements have been made across the 10 boroughs, but this particular update marks one of the biggest network upgrades that the likes of Alty and Hale have seen for some time.
Good news – we are thrilled to announce the installation of our first public EV charge points in collaboration with @TraffordCouncil.
Issuing a statement on Wednesday, 17 September, the firm – which specialises in managing, designing and maintaining complex facilities and transport infrastructure across the country – announced that they will “start the installation of EV charging points in Trafford in the coming weeks.”
It is expected that “up to 100 new public charges” will be integrated throughout the respective town centres and residential streets as the suburbs continues to push towards its sustainability goals.
As per Altrincham Today, Amey account director Anna Gornall said: “We’re excited to launch our first EV charge points in Trafford, working in partnership with Trafford Council (TC) to make electric vehicle charging more accessible to local communities.
“As the UK’s leading provider of energy transition and decarbonisation solutions, we’re well placed to use our existing expertise and resources to support TC in delivering a holistic public EV charging network for local communities.
“We’re helping residents make the switch, so everyone can plug in and power a greener Trafford.”
The country at large has various carbon-free initiatives, including the aspiration of achieving net-zero emissions by 2050; the electoral ward of Trafford itself continues to thrive in this field, having recently won environmental accolades, including 12 ‘Green Flag Awards’ this past July.
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Peter Anderson, Managing Director of Transport Infrastructure at Amey, commented: “This is a pivotal moment in Amey’s energy transition strategy. By leveraging our extensive experience in whole lifecycle asset management, strong partnerships, and innovative solutions, we can deliver value for both our clients and members of the public who will use Amey’s electric vehicle charge points.
“Working with Trafford Council, we are making electric vehicle charging more accessible to local communities and helping residents make the switch to EVs.
“Amey is well-positioned to support emerging opportunities within this landscape, and we are delighted to be working with Trafford and other local authorities to provide the public EV infrastructure needed to achieve the government’s transition to net zero.”
As for Trafford Council, Corporate Director of Place, Richard Roe, went on to add: “We are delighted to be working with Amey on this project to bring more and better charging options to the people of Trafford.
“This is an extension to the current EV charging options in the borough and is great news for committed EV owners and those who are thinking about going electric.”
Featured Images — Publicity pictures (via Amey Ltd)
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Further disruption expected as more bus strikes announced across Greater Manchester
Emily Sergeant
Further disruption is expected as even more bus strikes have been announced across Greater Manchester this autumn.
It comes after the strikes set to place this month from 19 to 22 September were announced a couple of weeks back, and now a second round will take place towards the end of this month and going into early October.
In case this is the first you’re hearing of the upcoming industrial action, 2,000 workers who are employed by Stagecoach, Metroline Manchester, and First Bus Rochdale – all of which are firms among those that make up the bus part of the Bee Network – are due to walk out in a co-ordinated strike amid an ongoing pay dispute.
Unite the Union says all the firms are ‘highly profitable’ and it’s therefore ‘disappointing’ that workers are being denied a fair wage.
More strikes have been announced on the Bee Network this month / Credit: TfGM
At Stagecoach, around 1,000 drivers based across the Oldham, Stockport, and Middleton depots have rejected a pay offer of 3.5%, and 1,000 Metroline Manchester members will also do the same after turning down an ‘unsatisfactory’ below-inflation pay offer.
Workers at both Metroline and Stagecoach believe the offer doesn’t address years of low pay they’ve recieved, especially given the ongoing cost of living crisis.
Then, over at First Bus Rochdale, 110 members have rejected this year’s pay offer of 6%, as they feel this does not go far enough to address the fact they’ve had years of being paid less than their counterparts at other companies, and are still the lowest paid in the region.
Stagecoach, Metroline, and First Bus Rochdale, part of First Group PLC, are all firms which have seen a rise in profits in recent years.
2,000 drivers are set to stage strike action over two different periods / Credit: TfGM
The second round of strikes will now take place from from 30 September to 2 October.
Speaking ahead of both sets of upcoming strikes, Unite General Secretary, Sharon Graham, said: “These companies are very profitable but are putting greed over their hardworking members of staff.
“Further strike action will be extremely disruptive, however this is a dispute entirely of the bus companies’ making and they could solve it easily by coming back with a better deal.
“Our members involved in the dispute have Unite’s complete support.”
Unite Regional Officer, Colin Hayden, added: “The strikes this week as well as the further action we have called will cause travel chaos in Greater Manchester. However, it is entirely the fault of the employers involved, who have failed to address the issue of low pay and reward their staff accordingly.
The Manc -
2nd December 2021 
