It’s been announced today that the Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK.
Following a rigorous review of its safety, quality, and effectiveness by the UK regulator and the government’s independent expert scientific advisory body, the Commission on Human Medicines, the treatment was found to successfully reduce the risk of hospitalisation and death in people with mild to moderate COVID-19 infection, who are at an increased risk of developing severe disease.
The treatment – known as Xevudy (sotrovimab) – has been developed by GSK and Vir Biotechnology, and is a single monoclonal antibody that, according to a statement published by the UK government website, works by binding to the spike protein on the outside of the COVID-19 virus.
This in turn prevents the virus from attaching to and entering human cells, so that it cannot replicate in the body.
Xevudy is the second monoclonal antibody therapeutic to be approved, following Ronapreve.
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In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection, and based on the clinical trial data, the government says sotrovimab is most effective when taken during the early stages of infection.
And so, the MHRA has said it recommends its use as soon as possible and within five days of symptom onset.
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BREAKING NEWS:
A new treatment against COVID-19 has been approved by @MHRAgovuk.
We'll closely monitor how effective Xevudy is against the Omicron variant and will work on deployment plans with the NHS.https://t.co/ZilAKtwdaO
The approval for use of this treatment follows the confirmation that the first pill to treat symptomatic COVID-19 – molnupiravir – has also been approved for use in the UK back at the start of November.
Like molnupiravir, Xevudy has been authorised for use in people who have mild to moderate COVID-19 infection, and at least one risk factor for developing severe illness – such as obesity, older age (+60 years), diabetes mellitus, or heart disease – but unlike molnupiravir, sotrovimab is administered by intravenous infusion over 30 minutes, and it has also been approved for individuals aged 12 and above who weigh more than 40kg.
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The MHRA says it’s too early to know whether the Omicron variant has any impact on sotrovimab’s effectiveness, but the body will work with the company to establish this.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a new COVID-19 treatment for use in the UK / Credit: Pixabay
“I am pleased to say that we now have another safe and effective COVID-19 treatment, Xevudy (sotrovimab), for those at risk of developing severe illness,” announced Dr June Raine, Chief Executive of the MHRA.
“This is yet another therapeutic that has been shown to be effective at protecting those most vulnerable to COVID-19, and signals another significant step forward in our fight against this devastating disease.
“With no compromises on quality, safety and effectiveness, the public can trust that the MHRA have conducted a robust and thorough assessment of all the available data.”
Featured Image – Flickr
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Castlefield is being transformed into Gotham amidst more Hollywood filming in Greater Manchester
Danny Jones
Castlefield, with its iconic viaduct and cobbled streets, is once again being used for big-budget filming as the latest Batman/DC Universe title, Clayface, looks to be setting up in the eye-catching Manc corner.
Whether it’s football kit reveals and brand shoots, BBC dramas or the next upcoming Netflix series, production crews can’t get enough of Castlefield, it would seem.
For those who hadn’t heard, work on the new Clayface movie revolving around the cult favourite Batman villain is well underway, and the North West has been used as the backdrop on multiple ocassions this month already.
You can see early glimpses of the set being put together down below.
Come on, how cool is it that we get to stumble on stuff like this right on our doorstep so often?
Speaking to The Manc, a source detailed that the set is being assembled today (Tuesday, 16 September) ahead of a single day of principal photography on what we can only assume is more Clayface filming sometime tomorrow.
While she could not confirm with us directly, she said, “If you’re a comic book nerd and look at the posters, you’ll be able to figure it out.” We’ve certainly been studying all the easter eggs already.
It might not quite be as dark and gritty as Gotham City, but this particular part of Manchester has been used in TV and film – especially period dramas – many times for good reason.
The Victorian-era steel structure, dark red brick and overall industrial aesthetic work so well when it comes to creating a believable and cinematic world.
Besides perhaps the most famous instance of Peaky Blinders shooting in these parts, you can add multiple music videos, several Manchester United and Man City shirt launches, and so many more that we’re starting to lose track.
As for Clayface, this isn’t even the first time the upcoming DC ‘body-horror’ flick has popped up in Greater Manchester.
Last week saw the equally striking Art Deco facade of the old The Plaza Super Cinema in Stockport turned into a fictional movie premiere to stunning effect:
Speaking of, another childhood favourite is filming here in Manchester right now, too.
Besides perhaps the most famous instance of Peaky Blinders shooting in these parts, the new Narnia adaptation by Greta Gerwig may just be one of the biggest projects that has ever landed underneath the familiar ‘birdcage’.
ln fact, it just so happens that there are actually multiple noteworthy small and silver screen works fighting over the Castlefield shooting schedule at the moment…
Manchester City staff member sacked after wearing Man United shirt to shift
Danny Jones
Man City have divided a fair few supporters after they sacked a barman for wearing a United shirt to their shift during the Manchester derby.
Although it’s not exactly surprising, the decision has ruffled plenty of feathers on both sides, as well as among neutral fans.
The Blues emerged victorious in the 197th clash between the two local rivals, winning 3-0 on an evening that paid tribute to the late, great Ricky Hatton, but another backstory looming over the fixture that caught the attention of football fans online was the City staff member who lost his job.
Working on concessions inside the Etihad Stadium before the game, the barman was made known to the official MCFC Matchday Support channel on X, who quickly confirmed he had been let go before the game even began.
In the since-deleted post, the home fan who reported the worker wrote: “Absolute joke – letting one of the bar staff in block 315 wear a United shirt on Derby Day.”
Although many City fans applauded the fast action by the club on the day, it’s fair to say that sacking him so soon that he didn’t even last until kick-off has rubbed many others the wrong way.
One Liverpool fan commented: “I hate United way more than City, but to sack him from a job because of an item of clothing is crazy. So, so poor from Manchester City, this. It’s just football lads, he’s not wearing a political or derogatory symbol. It’s literally a football team…”
Another neutral added: “Getting a minimum wage worker sacked for having a bit of fun instead of just winding him up is the absolute sad state this country is in.”
Even the ‘Out Of Context Football Manager‘ parody account chipped in, writing: “The guy’s been sacked for this. All he needed was a formal warning. I get he’s taking the p*ss – but losing a salary he might really need over this?!
While many have been even more outspoken in their response, as you can see, many supporters – be they Red or otherwise – have come up with arguably the perfect solution:
Manchester City are yet to comment on the backlash, apart from the initial confirmation that the still-anonymous staff member has been released from his position, but as for Man United, simply sticking him on the kiosks in the Stretford End could prove to be a very easy bit of positive PR.
Besides the growing frustration around the fanbase, as Ruben Amorim has yet to turn things around at Old Trafford (pressure was growing even before the derby day defeat), the Red Devils could no doubt do with some positive press for a change.
In fact, it was only earlier this year that co-owner Sir Jim Ratcliffe, CEO Omar Berrada and the wider INEOS Sports administration sanctioned a second round of redundancies at United, with approximately 450 individuals losing their jobs.
That being said, although some have labelled the sacking of the now ex-City barman as “absolutely horrendous behaviour” for Man City, many jumped to quip back that “[United are] more likely to sack more bar staff, not hire them”, as well as simultaneously taking aim at their significant transfer spending.
The Manc -
2nd December 2021 
