Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
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Manchester’s newest hotel launches massive recruitment drive with 100+ jobs available
Emily Sergeant
One of Manchester’s newest hotels has launched a massive recruitment drive with more than 100 jobs available to locals.
The Medlock, Manchester’s bold new 401-bedroom hotel – which is born from a partnership between Manchester City Football Club and Radisson Hotel Group, and is set to open later this year in the autumn – is looking for new team members across a wide range of areas, including front of house, housekeeping, engineering, and reservations.
To welcome these new team members onboard, the hotel has now launched a massive recruitment drive with dozens of roles available to local people.
Individuals who bring ‘authenticity, pride, and personality’ to everything they do are encouraged to apply for the roles – which go live early next week (Monday 27 April).
Aimed at boosting employment within the local community, vacancies span front-of-house, housekeeping, engineering and reservations.
The recruitment drive – delivered in partnership with Total People – is being lead by Valor Hospitality, the hotel’s operator chosen for its global expertise and people-first approach to hospitality, and will be offering tailored training programmes that are designed to make careers in hospitality accessible to Manchester residents.
Vocational qualifications across a range of skills will help individuals build confidence and step into rewarding roles in the industry, and it also means prior experience is not entirely necessary.
More than 100 roles will be available to local people / Credit: Supplied
General Manager Richard Pearson says the recruitment drive is a ‘unique opportunity to be part of an exciting partnership’.
“This is a milestone we’ve been eagerly anticipating, building the team that will bring The Medlock to life,” he added. “We’re looking for people who carry the spirit of Manchester with them, people who are proud of where they’re from and passionate about creating something special together.”
As mentioned, all job adverts will go live next Monday (27 April) so hopefuls can get their applications submitted here.
This’ll then be followed by invite-only open days for shortlisted candidates in mid May.
Featured Image – Supplied
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UK passes bill to ban everyone born after 2008 from smoking in ‘historic’ moment
Emily Sergeant
In what is described as being a ‘historic moment’, the UK has now passed a bill to ban everyone born after 2008 from ever buying tobacco products.
It’s been a long time coming, but the final draft of the landmark Tobacco and Vapes Bill completed its journey through the Houses of Commons and Lords yesterday (21 April 2026), and is now on its way to receiving royal assent to officially become the law.
For those unfamiliar, the Tobacco and Vapes Bill will stop people who were born on or after 1 January 2009 from ever taking up smoking.
It will also give Government ministers new powers to regulate tobacco, vaping, and nicotine products – including their flavours and packaging, which make them more appealing to younger generations.
Health Secretary Wes Streeting has hailed the bill’s passing as a ‘historic moment for the nation’s health’ on the road to creating a smoke-free generation.
The UK has passed a bill to ban everyone born after 2008 from smoking / Credit: Lil Artsy (via Pexels)
“Children in the UK will be part of the first smoke-free generation, protected from a lifetime of addiction and harm,” Mr Streeting said after the bill was passed this week.
“Prevention is better than cure. This reform will save lives, ease pressure on the NHS, and build a healthier Britain.”
The ban on purchasing tobacco products for those born after 2008 was first mooted by Rishi Sunak’s Conservative Government a number of years back, but was eventually shelved ahead of the 2024 General Election, and then revived again by Labour when they took power.
The bill’s passing parliament has been welcomed by charities and campaign groups – most notably Cancer Research UK.
“This is a historic achievement that will shield our children from the devastating grip of tobacco addiction and help to put an end to cancers caused by smoking,” concluded Michelle Mitchell, who is the Chief Executive Officer at Cancer Research.
The Manc -
19th April 2021 
