Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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The Premier League is keeping its crucial cap on away game ticket prices – for now
Danny Jones
The Premier League has announced it is extending its crucial price cap for away games, as the general cost of match tickets continues to creep up all over the country.
Most season card holders, be they here in Greater Manchester or elsewhere, are likely looking at their annual spending going up simply, so steps like these are key in keeping first division football as affordable as possible.
And that’s just the ongoing cost of living, let alone the clubs that are continuing the trend of charging more each year and, unfortunately, even pricing some supporters out entirely.
With that in mind, the news of England’s top-flight sides voting unanimously to keep the £30 cap intact for at least another two years comes as relief to those who spend most of the year putting their hard-earned cash towards following their team home and away.
BREAKING: The Premier League extend £30 cap on away tickets for another two seasons 🚨 pic.twitter.com/L336aZwmn3
Now confirmed to remain in place until the end of the 2027/28 campaign, travelling fans obviously still spend plenty of money on transport and so on every year, but at least they don’t have to worry about rising general admissions.
At least not for the time being…
Writing in a statement, the Premier League said: “Away fans help create the incredible atmosphere Premier League matches are renowned for. Since the cap’s implementation in 2016, it has contributed to attendance at away games increasing from 82% to 91%.”
They also acknowledged the significant and regular funds that supporters still spend on these trips, with plenty of people online also praising the Football Supporters’ Association (FSA), which helped spearhead the campaign over a decade ago.
With so many other obstacles still getting in the way of fans making it to games either at their usual stadium or on an away day – not least of all the constant and increasingly frustrating rescheduling of fixtures – it’s good to see this isn’t an area the Prem are trying to target.
As always, the multi-billion-pound business can always seek out other, newer money spinners, and we’re absolutley certain they will. For instance, there’s at least one happening over in Spain that we’d happily see carried over here.
Following the news, this now means that fans will ultimately have enjoyed 12 back-to-back seasons of the benefit, and long may it continue.
Nevertheless, the biggest barrier for people to watch the beautiful game at its highest level in the UK remains the cost of standard tickets.
The likes of Manchester United, Arsenal, Leeds and more have already let matchgoers know that their season ticket prices will be going up, and the likes of Man City have already seen backlash for increasing rates amid the expansion of the Etihad Campus.
Greater Manchester’s fire service officially rated ‘outstanding’ following inspection
Emily Sergeant
Greater Manchester’s fire service has officially been rated ‘outstanding’.
His Majesty’s Inspectorate of Constabulary and Fire & Rescue Services (HMICFRS) has awarded published its latest inspection report, and has awarded Greater Manchester Fire and Rescue Service (GMFRS) two ‘Outstanding’ ratings for the first time in the service’s history.
One ‘outstanding’ rating was given for the preventing of fire and emergencies, and one for values and culture.
Some of the areas of strength noted in the report include outstanding prevention work, acknowledging the service’s innovative partnership activity and targeted risk reduction programmes, and a ‘strong, positive, and inclusive’ culture, with strong communication and a clear focus on values, staff voice, and transparent decision making.
The service was also commended for having high levels of operational preparedness, and ‘effective’ governance and scrutiny, with ‘clear’ performance reporting and strategic direction.
In addition to the two ‘Outstanding’ ratings, inspectors also rated GMFRS as ‘Good’ in seven of the eight other inspection categories – including responding to fires and other emergencies, training and developing the right people with the right skills, and ensuring fairness and diversity across the workplace.
Inspectors also acknowledged the ‘significant capacity pressures’ on fire safety regulation across the UK, and the unique challenges posed by Greater Manchester’s complex and fast-changing urban environment.
“Greater Manchester has a fire and rescue service we can be proud of,” commented Mayor Andy Burnham, as the inspection report was published this week.
Greater Manchester’s fire service has officially been rated ‘outstanding’ following its latest inspection / Credit: GMFRS
“I’ve often said that GMFRS is one of the best services not just in this country, but anywhere. The inspectors’ findings reinforce this belief. I’m pleased that this strong inspection report recognises its outstanding prevention work as part of Greater Manchester’s Live Well approach, its outstanding culture and values, and consistently good performance across almost every other area.”
Chief Fire Officer, Dave Russell, added: “I am really pleased that the inspectors have recognised our progress towards this goal, by awarding us ‘Outstanding’ ratings for the first time in our service’s history.
“I am particularly pleased to have been awarded these for our nation-leading work on prevention, helping us to use our resources in the most effective way, and in our service’s culture, which I made my number one priority when joining the service.”
Daisy Jackson -
30th November 2022 
