Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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Hundreds of staff at four Greater Manchester hospitals to strike AGAIN next week
Emily Sergeant
Another round of strikes has been called at a handful of major Greater Manchester hospitals.
Amid ongoing disputes following the first set of strikes at the end of last month, it has now been announced that more than 350 Northern Care Alliance Foundation Trust (NCA) employees – including nurses, clinical support workers and housekeepers – who are members of the union UNISON will once again walk out for three days next week.
According to the union, the dispute centres on the NCA’s use of an outside agency called NHS Professionals (NHSP) to manage overtime.
When covering staff shortages, workers are entitled to time-and-a-half pay – however in some cases, staff earn less than they would on a normal shift, and some have even been missing out on more than £80 per shift, the union added.
Operating theatre staff were previously on picket lines in June, and although an option to resolve the row was initially tabled by NCA bosses, this has now fallen through.
Hundreds of staff at four of Greater Manchester’s hospitals are set to strike next week / Credit: Stephen Andrews (via Unsplash)
This means that staff at Salford Royal Hospital, Royal Oldham Hospital, Rochdale Infirmary, and Fairfield Hospital in Bury are walking out next week on Monday 14, Tuesday 15, and Thursday 17 September.
The union’s North West regional organiser, Kevin Dolan, said the trust had given ‘no indication’ that it’s willing to re-enter negotiations, adding that operating theatre services were ‘chronically under-staffed’ and staff were choosing to work extra shifts to cover shortages.
Ahead of the August strikes, the trust declared a critical incident to help it secure extra support and keep urgent surgery running, while also announcing that some procedures would have to be postponed.
Understandably, some disruption is expected at each of the hospitals on strike days.
But Gertie Nic Philib, who is the chief people and strategy officer at the Northern Care Alliance, said that the trust will do ‘everything we can to minimise the impact on patients’ and ‘maintain high standards of care and quality at all times.’
“We also have contingency plans in place for emergency situations,” they concluded.
Featured Image – Pxhere
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Stockport man jailed for life after kidnapping and sexually assaulting teenage girl
Emily Sergeant
A Stockport man has been sentenced to life in prison after kidnapping and sexually assaulting a teenage girl on her way home from the library.
Paul Sharpe has been sentenced to life imprisonment with an eight-year minimum term in prison after being convicted of a number of offences when subjected a teenage girl to what police called a ‘terrifying ordeal’ that lasted several hours back in May 2026.
Greater Manchester Police (GMP) confirmed that the victim had been studying at Sale Library before beginning her journey home with friends at around 5:50pm and contacting her parents at 6:10pm to let them know she was on her way.
Twenty minutes later, she spoke to her boyfriend on the phone and said she was approximately five minutes away from home, but that her phone battery was about to die.
This was the last contact received from the victim that evening.
While walking along Bradgate Road in Altrincham, the victim noticed a grey Ford parked nearby and a man wearing a high-visibility jacket pressing doorbells in the area.
As she walked past, Sharpe approached her from behind, placed her in a headlock and threatened to stab her if she did not get into his vehicle.
Concerned that their daughter had not returned home, the victim’s family contacted police at 9:22pm to report her missing, and officers immediately launched an investigation to locate her.
Over the next several hours, the victim was subjected to and placed in a number of terrifying situations.
Sharpe drove the victim to several locations across Greater Manchester and Cheshire, before police located and arrested him at around 3:40am on 19 May 2026.
Following his arrested, 56-year-old Sharpe was convicted of kidnap, committing an offence with intent to commit a sexual offence, sexual assault, engaging in sexual activity in the presence of a child, threats with a bladed article, and administering a noxious substance with intent to injure, annoy or aggrieve.
“This was a terrifying ordeal for a young girl who was simply making her way home,” explained Detective Inspector Karl Perry, from GMP’s Criminal Investigation Department.
“Sharpe targeted a vulnerable victim, subjected her to hours of fear and intimidation, and went on to sexually assault her.
“The victim has shown immense courage throughout the investigation and court proceedings. Through her bravery and actions, she no doubt made it harder for Sharpe to carry out whatever acts he had planned.”
Daisy Jackson -
30th November 2022 
