Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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Greater Manchester restaurant speaks out after being paid a visit by Nigel Farage
Daisy Jackson
A restaurant in Greater Manchester has issued a lengthy statement after it was paid a visit by Nigel Farage on his campaign trail.
Vault 2, a family-run business in Denton, has said that it’s been bombarded with negative messages since the Reform party leader was photographed inside the restaurant.
Farage had made appearances at a number of local businesses in Tameside, alongside the party’s candidate, Matt Goodwin.
Vault 2 stressed in its statement about Nigel Farage that it is ‘a restaurant, not a political platform’, adding: “We hold no prejudice toward anyone – regardless of political views, race, background, creed, or beliefs. Everyone is welcome through our doors, and anyone may privately hire our venue. That has always been the case and will remain so.”
The restaurant also clarified that it was not a hosted event that Farage attended, nor were they endorsing or supporting him by allowing him to ‘call in’.
Vault 2 added: “It is genuinely upsetting, after everything we have done – and continue to do – for this town, to receive accusations of favouritism or messages saying you’ll never visit us again based on this.”
The restaurant then said that it takes ‘no political stance, shows no favour, and aligns with no party’ – though critics have pointed out that its Facebook page had shared a Reform post just before making this statement.
Inside Vault 2 last yearFood at Vault 2Vault 2 has issued a statement about the Nigel Farage visit. Credit: The Manc
Vault 2 signed off its statement by saying: “Whether you vote left, right, centre, or not at all — you are welcome here. Food first. Hospitality always. Thank you x.”
One person commented on the post: “If your doors are open to fascists, then your doors are closed to their targets. I sincerely hope your business suffers for it.”
Another said: “How can you ‘create a welcoming space’ if you welcome people whose aim to create the exact opposite.”
And someone else said: “This would be more believable if you weren’t liking Reform posts on Facebook. If you take no political stance and align with no party, maybe don’t like posts about Goodwin from your business account. We see you.”
But several people showed support for Vault 2, with one writing: “Well said – shame on those sending negativity – the keyboard warriors need to take a break and disappear!”
Vault 2’s statement in full addressing the visit from Nigel Farage. Credit: Instagram @vault2_barandbistro
Ticket requests are now officially open for Harry Styles’ one-night-only Manchester gig
Emily Sergeant
The time has come – the ticket request system for Harry Styles’ one-night-only gig in Manchester is now live.
In case you hadn’t heard, it was announced on Wednesday evening after much speculation that Harry Styles would be making a return home to Manchester for a one-night-only ‘intimate’ gig at Co-op Live to celebrate the release of his fourth studio album next month.
Styles is set to share Kiss All The Time. Disco, Occasionally with the world on Friday 6 March – and it’s that very same night he’ll be taking to the stage in Manchester.
Although little is known about what to expect at the gig, the poster for the event does state that there’ll be a ‘special performance of the album’, so it seems fair to say that Manchester will be the first to hear the new set of songs in full live.
And if all of that wasn’t exciting enough as it is, the tickets are only £20 per person.
But, of course, there is a bit of a catch, as this isn’t your regular online queuing up for tickets scenario, this is a ‘ticket request’ system instead.
So, like us – and literally every other fan in the vicinity of Greater Manchester and beyond this week – you’re probably wondering what a ‘ticket request’ system is… what does it look like? How does it work? Basically, what the heck is it? Well, we’ve done a bit of digging around to get to the bottom of it so you’re not left too much in the dark.
According to Ticketmaster’s website, if an artist is running a ticket request, they’ll invite fans to request tickets so you don’t have to compete in a first-come, first-served sale.
This means you can take your time to review the available options and request the right tickets for you.
All you need to do is tell Ticketmaster which shows you’re interested in, the type of ticket you want, and your payment details. Then, if the tickets you request can be fulfilled, your card will be charged and you’ll get emailed instructions to access them in the Ticketmaster App.
Unfortunately, as much as we’d love it to be the case for everyone, submitting a request doesn’t guarantee you tickets – it really is just luck of the draw.
To request tickets, you’ll need to follow these three simple steps:
Select which shows you’re interested in and the type of ticket you want
Add your payment details
Harry Styles ticket requests are now live / Credit: Johnny Dufort (Publicity Picture)
Ticketmaster will then send you a summary email that details the tickets you’ve requested. Your card won’t be charged at this time, but they may charge a temporary £1 authorisation to your card to validate your request.
A maximum of two tickets per person can be requested, which has been set to allow for as many fans as possible to get tickets.
Now, here’s the crucial part – you will need to submit your request for tickets while the window is open until Sunday 8 February at 11pm GMT. After the request window closes, you’ll get a second email by 11:59pm GMT on Tuesday 10 February confirming whether or not your request has been fulfilled.
Daisy Jackson -
30th November 2022 
