Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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Trainline and Virgin Atlantic among companies being investigated for ‘misleading’ pricing
Emily Sergeant
A number of companies are currently under investigation for ‘misleading’ pricing practices.
The Competition and Markets Authority (CMA) has launched three new consumer protection investigations into Trainline, Virgin Atlantic, and RED Driving School over concerns that customers were not shown the total price upfront when buying things like train and coach tickets, holidays, or even driving lessons.
The investigations are part of a wider CMA clampdown on misleading pricing practices – in this instance, where mandatory charges are separated from the headline price, or added later in the buying process, which is known as drip pricing.
These practices leave consumers facing ‘unexpected’ costs or having to calculate the so-called true cost themselves.
Such practices can also impact competition between businesses, as a firm using drip pricing may falsely appear to be cheaper than a competitor pricing correctly, and therefore attract more customers.
Trainline and Virgin Atlantic are among the companies being investigated for ‘misleading’ pricing / Credit: Northern | Aric Cheng (via Unsplash)
Trainline is being investigated over whether all mandatory fees have been included in the upfront prices displayed to consumers buying tickets in advance on its app and website, while Virgin Atlantic’s investigation will focus on whether mandatory resort fees and local taxes have been included in the upfront prices shown to customers buying package holidays.
RED Driving School is being investigated over how a mandatory booking fee and ‘digital’ fee have been displayed to people booking driving lessons – specifically whether these fees have been included in the total upfront price.
“At a time when many households are watching every pound they spend, it is important that people are not surprised by extra fees,” commented Emma Cochrane, who is the Executive Director for Consumer Protection at the CMA.
“Clear pricing helps people compare offers confidently and choose the option that works best for them.
“Unexpected mandatory charges make this much harder, which is why the CMA initially put these firms on notice over concerns about their pricing practices and is now opening formal investigations.”
The CMA says it’s at the beginning of its investigations and has reached no conclusions about whether these firms have broken the law.
If it finds there has been an infringement of the law, the CMA can order businesses to pay compensation to affected customers or be charged up to 10% of global turnover.
Featured Image – PNW Productions (via Pexels)
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The ENTIRE Manchester Village Pride lineup cost £20k less to book than ONE headliner last year
Daisy Jackson
Bosses behind Manchester Village Pride have revealed that the entire lineup has cost significantly less than the amount spent on just one headliner last year.
In a statement promising transparency, organisers said that the entire weekend of artists has cost less than one single headliner from 2025.
And by some margin – £20,000.
The announcement comes less than a year after the previous Manchester Pride organisation entered voluntary liquidation amid rising costs, declining ticket sales and an ‘ambitious refresh’ of the festival format.
That refresh included moving the main music portion of the annual LGBTQ+ celebration away from the Gay Village itself, and over to Depot Mayfield.
The collapse of Manchester Pride followed reports that performers from the 2025 event were still waiting to be paid, with entertainment union Equity later saying its members were more than £70,000 out of pocket.
Manchester Village Pride was subsequently established as a not-for-profit Community Interest Company, with organisers promising a more community-focused approach and greater transparency around finances.
The 2026 event is being delivered with unpaid directors, while organisers have also signed an Equity agreement guaranteeing fair pay and professional standards for performers – the first UK union agreement of its kind for a Pride event.
Performing at Manchester Village Pride this year are major artists like Nadine Coyle, Danny Beard, Gareth Gates, Kate Nash, Cascada, and Rowetta.
They’re joined by a lineup of fantastic home-grown talent, including artists, DJs, and drag queens, taking our city’s Pride celebrations back to their roots, and keeping things firmly in the Gay Village.
In their statement, Manchester Village Pride said: “Transparency time! Booking this entire weekend of fabulous artists cost us £20k UNDER what was spent on a single headliner last year. This is what community Pride looks like!”
Manchester Village Pride will once again take place over the August bank holiday weekend, with the party running for four days from Friday to Monday.
The celebrations will culminate in the moving candlelit vigil in Sackville Gardens.
Ticket prices this year, even with just over a week to go, are only £40 for the full three-day festival, or £25 for one day. Monday will be free to attend.
Daisy Jackson -
30th November 2022 
