Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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2024 Manchester Marathon raises £29 million for local economy and over £3.7m for charity
Danny Jones
Just under a fortnight on from the 2024 Manchester Marathon and the numbers are finally, with the annual race generating nearly £30 million for the local economy and raising over £3.7m for charity.
This year’s Adidas Manchester Marathon saw record numbers of runners and spectators as over 30,000 took part in the popular race, up by roughly 6,000 from 2023, and more than 125k turned up to line the streets of Greater Manchester.
As a result, these huge crowds spent upwards of £29.2 million at business around the city centre and around the 10 boroughs last weekend, serving as one of the most significant contributions to the local economy on the annual calendar.
Not only was this an approximately £8m increase on last year’s tally but, most importantly, a sizeable chunk of that went straight into both regional and national charities.
The 2024 adidas Manchester Marathon was a spectacular day for the city and its economy.
Beyond the boost to local vendors, the hospitality sector and retail businesses, over £3.7 million were allocated to charities such as Alzheimer’s Charity, Cancer Research UK, British Heart Foundation and The Christie.
Over £32,000 was also raised for the Trafford Active Fund, with £1 from every paid entry to the Adidas Manchester Marathon and Manchester Half donated directly to the initiative that benefits local sports clubs and organisations through Trafford Council.
Better still, with City of Trees selected as the chosen ‘Green Runner’ charity, the eco-friendly drive saw roughly 7% of participants opt out of receiving either a finisher t-shirt, medal or both.
The money saved in production goes towards maintaining woodlands and wildlife across Greater Manchester.
Together you have raised over £3.7 million for charitable causes, adding even more meaning to those 26.2 miles 💕 Well done and thank you to all those who fundraised and donated! 🌟Tag us in those charity top pictures from last weekend 😍😍#ManchesterMarathonpic.twitter.com/5gsi6NtFzB
This year’s Manchester Marathon also helped produce some of the highest number of passengers on public transport in the city’s history, with a over 175,000 journeys made on Metrolink alone – the highest number of journeys ever recorded on a single day.
This was a 20% increaseon 2023’s race day (145k), spotlighting how the event continues to be more environmentally conscious as years go by.
With the 2025 adidas Manchester Marathon confirmed to be taking place on Sunday, 27 April next year – and over 12,000 places already sold – the city can already look forward to reaping the economic and social benefits of hosting one of Europe’s largest, flattest, friendliest and most-loved marathons.
Featured Images — Adidas Manchester Marathon/The Manc Group
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Manchester firefighter surprises partner with proposal during new recruits parade
Danny Jones
We’re a sucker for a wholesome little video as we know you are, which is exactly why we thought of you lot when we came across this video of a newly graduated Manchester firefighter surprising his partner with a heartwarming proposal.
Just the kind of heartwarming that usually sets us off after a long week at work.
The clip shared by Greater Manchester Fire and Rescue Service (GMFRS) on Thursday, 25 April, shows Manc fireman James popping the question to his girlfriend sat unassumingly in the audience at a recent passing out ceremony.
Pass out ceremonies are when trainees go from recruits to fully qualified firefighters after completing their intensive operational training. It’s a long-standing tradition in the emergency services where friends and family gather to celebrate their achievements – it’s almost like it’s the perfect opportunity…
Watch as a Manc firefighter turns his passing out ceremony into a surprise proposal.
As you can see, since the graduates are usually the centre of attention, James couldn’t help but size his moment and instead of walking and lining up normally like everyone else, he decided to head straight over to his wife-to-be and get down on one knee.
You already know the rest.
Welling up immediately and barely able to remove her hands from her face, Melissa nods and says yes as the crowd cheers and the pair share a smooch.
Writing on social media, the GMFRS said: “We managed to capture a VERY special moment at our new recruits pass out parade today… Congratulations to James and Melissa!”, adding, “Certainly one way to start your new career”.
If we don’t see all the groomsmen dressed as firefighters on a random viral video sometime soon we’re going to be gutted.
All the best to the happy couple and if you’ve got any more lovely clips like this to send in so we can make ourselves cry (in a good way), you know what to do.
Daisy Jackson -
30th November 2022 
