A warning has been issued after a batch of ‘Punisher’ ecstasy pills in Manchester were found to be up to five times stronger than the normal dose.
The pills were found at ‘multiple’ nightlife venues across Greater Manchester.
Scientists have warned that the drugs, which contain up to 477mg of MDMA per tablet, will ‘increase risk of death’.
The ‘Punisher’ pills are thicker in appearance than normal ecstasy pills, and contain between four and five times more MDMA.
They are embossed with the skull of Marvel anti-hero The Punisher.
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WARNING! 12/11/2021. Multiple Blue “Punisher” embossed “thicker” tablets (LHS) confirmed by @MANDRAKE_LAB, to contain #MDMA (397 – 477 mg/tab) = to 4-5x the common oral dose. Even ½ of these pills is v. high dose. High dose will not increase effect but increases risk of death. pic.twitter.com/23fThTN4XW
Researchers from MANDRAKE (Manchester Drug Analysis and Knowledge Exchange), based at Manchester Metropolitan University, posted the warning over the weekend.
They wrote: “WARNING! 12/11/2021. Multiple Blue “Punisher” embossed “thicker” tablets (LHS) confirmed by @MANDRAKE_LAB, to contain #MDMA (397 – 477 mg/tab) = to 4-5x the common oral dose. Even ½ of these pills is v. high dose. High dose will not increase effect but increases risk of death.”
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MANDRAKE has been partnering with Greater Manchester Police to ‘understand the progression of psychoactive substances that are in circulation on the illegal drugs market’.
People have been warned about the ‘Punisher’ ecstasy pills. Credit: Unsplash
The huge club venue at Depot Mayfield also works with W.E.L.Safe to provide confidential and non-judgemental advice on drugs, alcohol and other issues.
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Speaking to Vice, Fiona Measham, director at drug testing NGO The Loop, said: “It’s likely to be amongst the highest in the world.”
She added that she expects the super-strength, thicker pills were made by mistake.
She said: “The customer doesn’t usually know the strength of ecstasy pills bought on illicit markets and reagent tests can’t help with that. So their life is in danger because of the absence of one simple fact: the MDMA content of the pill they bought.
“If a customer uses a drug checking service and finds out the strength of a pill is 477mg, then they can simply divide it into quarters and they have 4 average adult doses of MDMA, with no more risk than any other 120 mg pill.
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“Knowledge is power, but lack of information on strength can transform a pill from benign to deadly.”
Speaking back in July, when nightclubs reopened, MANDRAKE’s director Dr Oliver Sutcliffe said: “Our team of scientists are extremely proud to be both a key part of the Greater Manchester Drugs Early Warning System and the GMP night time economy plan as COVID restrictions are lifted.
“We hope that our laboratory, which will be working closely with partner organisations in all ten Greater Manchester boroughs, will be able to rapidly provide robust data to help improve drug awareness amongst our communities, and enhance and inform harm reduction schemes across the city region.”
Featured Image: Unsplash / MANDRAKE
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New endometriosis pill helping hundreds of women with ‘debilitating’ condition to be made available on NHS
Emily Sergeant
A groundbreaking new pill to help women with a ‘debilitating’ condition is set to be made available on the NHS.
The new daily pill for endometriosis – which has been approved for use on the NHS in England by the National Institute for Health and Care Excellence (NICE) – is called linzagolix, and will be available for those who have had previous treatment for endometriosis, working to manage any symptoms they may be experiencing.
Around 1.5 million women in the UK are thought to be currently living with endometriosis.
Endometriosis can cause chronic pain, heavy periods, and extreme tiredness when tissue similar to the womb lining grows elsewhere in the body.
A new daily pill for endometriosis has been approved for use on the NHS, and could help over a thousand women in England every year manage the symptoms of the debilitating condition.
As mentioned, linzagolix will be available specifically for patients whose previous medical or surgical treatments for endometriosis have been unsuccessful, and will be given alongside ‘add-back’ hormone therapy – which involves using low-dose hormone replacement therapy (HRT) to prevent menopause-like symptoms and bone loss.
This is the second take-at-home treatment to be approved to treat endometriosis on the NHS, and it’s thought that more than 1,000 women will benefit.
In clinical trials, linzagolix was shown to be successful in reducing painful periods and non-menstrual pelvic pain, compared with placebo, hence why it has been approved on the NHS by NICE.
“This is welcome news for women with endometriosis who haven’t found relief from previous therapies or surgery,” commented Dr Sue Mann, who is the National Clinical Director in Women’s Health for NHS England.
“It’s another treatment option which will help women take control of their health and better manage the symptoms of this often painful and debilitating condition.
“This is a testament to our ongoing commitment to improving treatment, care and quality of life for women.”
Featured Image – Heute
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Wigan woman jailed after hitting pedestrian in Fiat 500 while driving high on nitrous oxide ‘balloons’
Emily Sergeant
A young woman from Wigan has been handed jail time after hitting a pedestrian while driving high on nitrous oxide.
Louisa Tunstall was driving a white Fiat 500 towards the East Lancashire Road in Wigan at around 7pm on Friday 24 May 2024 – a time when traffic conditions were said to be ‘quiet’ – but Tunstall was under the influence of a now-banned drug, nitrous oxide, at the time of the incident, Greater Manchester Police (GMP) confirmed.
While driving under the influence, 19-year-old Tunstall veered to the left onto the pavement and collided with a 51-year-old woman pedestrian.
After striking the woman, the car then overturned and, in the process, caused serious life-changing injuries.
When questioned by police, Tunstall stated that she ‘took her eyes off the road’ to retrieve something in the footwell before knowing the car had flipped, but she also confirmed that she had just been out to purchase nitrous oxide to use that evening.
After obtaining witness accounts, investigating officers were able to track down nearby CCTV footable which showed Tunstall inhaling nitrous oxide through a balloon whilst driving, seconds before the collision occurred.
#JAILED | It's not a laughing matter when you get behind the wheel under the influence of drugs.
Now Louisa Tunstall has to spend over a year behind bars after inhaling nitrous oxide and causing serious injury in #Wigan last year.
— Greater Manchester Police (@gmpolice) May 14, 2025
Further investigation by GMP’s Forensic Vehicle Examination Unit examined the Fiat 500 and confirmed that no defects were found on the car to contribute towards the collision.
Still to this day, the victim says she is trying to recover from the injuries sustained to her leg that will prevent her from continuing life as she did before.
“The incident is still very raw when I think about it,” the victim explained in her impact statement released by GMP. “I become upset when I think at everything which has been taken away from me and the ongoing affect it has had and continues to have on my daily life.”
GMP says it’s seeing the use of nitrous oxide being a factor in incidents they attend increasing year on year.
Nitrous oxide, also known as ‘laughing gas’, is reported to produce euphoria, relaxation, dizziness, giggling or laughing fits, impaired judgement, and occasionally dissociation and hallucinations – which GMP says affects reaction time and and is ‘likely lead to impairment’ in driving performance, particularly when faced with an unexpected or hazardous situation.
Tunstall appeared at Bolton Crown Court this week, and has been sentenced to one year and eight months imprisonment for having possession of a Class C drug, driving under the influence of drugs, and causing serious injury by dangerous driving.
Alongside being jailed, she was also disqualified from driving for two years and eight months, and has been ordered to take an extended test when she is released.
Daisy Jackson -
17th November 2021 
