Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
News
Manchester United legend Denis Law has died aged 84
Emily Sergeant
Manchester United legend Denis Law has sadly died aged 84, it has been announced.
The Aberdeen-born footballer was a prolific striker throughout his career, scoring 237 goals in 404 appearances for Manchester United – the club he signed for a then-British record transfer fee back 1962, before departing in 1973 – and also playing for Manchester City too for two separate spells during the 1960-61 and 1973-74 seasons.
Law was an integral part of United’s triumphant record-setting 1968 European Cup winning campaign, was the only Scottish player to have won the Ballon d’Or award, in 1964, and also the only man to have two statues dedicated to him at Old Trafford.
But, he previously announced in August 2021 that he had sadly been diagnosed with dementia.
The whole of Manchester, including everyone at City, is mourning with you. Rest in peace, Denis. Our thoughts are with Denis’ family and friends at this difficult time. pic.twitter.com/YuwjMXKgxn
A formal statement confirming Law’s passing by his family was announced by Manchester United this evening: “It is with a heavy heart that we tell you our father Denis Law has sadly passed away. He fought a tough battle but finally he is now at peace.
“We would like to thank everyone who contributed to his wellbeing and care, past and much more recently.
“The ultimate goal-scorer, his flair, spirit and love for the game made him the hero of a generation. Our deepest condolences go out to Denis’s family and many friends. His memory will live on forever more.”
Advice issued as ‘quademic’ of winter bugs continues to take hold in Greater Manchester
Daisy Jackson
People in Greater Manchester are being urged to get any vaccinations they are due done, as a ‘quademic’ of winter bugs runs rife.
Cases of flu, Covid, norovirus and RSV (respiratory syncytial virus) are continuing to take hold across the country, and here in Greater Manchester.
The city is seeing more flu cases and hospital admissions than usual for this time of year.
So now health chiefs are urgently reminding eligible people to get their flu jabs and other vaccinations, to protect themselves and others.
Mancs are also being reminded to follow key public health advice, such as frequent hand washing and staying at home when you’re ill.
The flu vaccination drive runs until the end of March and people who are eligible for it can get it from their GP, pharmacy or one of the city’s walk-in clinics, where no appointment is needed.
Dr Cordelle Ofori, Manchester’s Director of Public Health, said: “Our advice is very similar to recommendations made during the Covid pandemic.
“It’s really important to keep washing hands well and regularly; cough or sneeze into tissues or your arm; wipe down key communal surfaces like handles on doors; and where possible, stay at home if you are ill to avoid passing on any infections.
“And, in addition to this we would urge anyone who is also feeling financial or food pressures to ring our free cost of living advice line on 0800 023 2692 or text on 07860 022876.”
Councillor Thomas Robinson, Executive Member for Healthy Manchester and Social Care, at Manchester City Council, said: “Manchester people are well-known for how they look after one another – and passing the flu message on could save lives, as well as unnecessary illness at a time when people face many pressures.
“We want to make it as easy as possible for people to have their vaccination, so please do go to our walk-in clinics if you are 18 and over and eligible for the vaccine. No appointment is needed: it’s quick, easy and done by teams who want to help you.”
The Manc -
19th April 2021 
