Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
News
Police appeal to find next of kin after man found outside Palace Theatre
Daisy Jackson
Police are trying to track down the family of a man who died after being found unresponsive outside the Palace Theatre in Manchester.
The man, who has now been named as Jonathan Bernard Carroll, was seen outside the city centre theatre at around 6.30am on Tuesday 12 November.
Emergency services rushed to the scene and Mr Carroll was taken to hospital.
Tragically, the 47-year-old passed away a short time later.
A large cordon was in place on Whitworth Street and Oxford Road while police and security attended the incident.
Greater Manchester Police are now appealing to find his next of kin.
It’s believed that he resided in the Salford area of Greater Manchester.
Anyone with any information should contact the Coroner’s Office on 0161 856 1376.
Greater Manchester public urged to help get people ‘off the streets and on their feet’ before Christmas
Emily Sergeant
Locals are being urged to help get hundreds of people “off the streets and back on their feet” this festive season.
As the temperatures told colder by the day, and Christmas creeps closer and closer, Greater Manchester Mayor’s Charity is bringing back ‘1000 Beds for Christmas’, and the massively-important initiative is aiming to provide 1,000 nights of accommodation to people at risk of homelessness before the big day arrives.
Forming part of the ongoing ‘A Bed Every Night’ scheme, this festive fundraising mission is designed to provide food, shelter, warmth, and dedicated vital wrap-around support for those who need it most.
The charity says it wants to build on the “incredible success of 2023”, which raised more than £55,000 and provided 1,800 nights of accommodation.
Stockport-based property finance specialists, Together – which has supported the campaign for the last two years – has, once again, generously pledged to match every public donation for the first £20,000 raised.
Unfamiliar with the ‘A Bed Every Night’ scheme? Since 2017, when rough sleeping peaked, the initiative has helped ensure a significantly-higher rate of reduction in the numbers of people facing a night on streets in Greater Manchester than seen nationally.
The landmark scheme has given people the chance to rebuild their lives, while also giving them access to key services and opportunities that allows them to stay off the streets for good.
Despite the scheme’s recent success, organisations across Greater Manchester are under “a huge amount of pressure” to meet the demand for their services this winter, and given the current economic outlook, household budgets will continue to be squeezed – leaving people on the sharp end of inequality and poverty.
The Manc -
19th April 2021 
