Young people who have previously had COVID-19 are to be deliberately exposed to the virus for a second time.
It’s all part of a new study that aims to monitor how their immune systems react.
The University of Oxford’s “human challenge” trial – which is being widely reported on this morning – also hopes to discover what dose of coronavirus (COVID-19) is needed to cause a reinfection, and what this may mean for developing protective immunity against the disease.
The decision to carry out the study comes after recent research has suggested that prior infection may not fully protect young people from COVID-19 in the future, with an observational study performed in the US indicating that 10% of participants ended up getting reinfected.
So, what does the study entail then?
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As part of the trial, young people – between the ages of 18 to 30 – who have previously already been naturally infected with COVID-19, will be recruited and then re-exposed to the virus in a safe, controlled environment, all while being quarantined for 17 days and cared for by researchers at a hospital until they are no longer at risk of infecting others.
Once the trail is complete, participants will then receive just under £5,000 as payment.
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The study will take phase in two phases.
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The first phase – which will involve 64 healthy volunteers – aims to establish the lowest dose of virus which can take hold and start replicating, and once the dosing amount is established, it will be used to infect participants in the second phase of the study.
Regular check-ups in the year after reinfection will also help to establish the immune response generated by the virus, as well as contributing to the creation of better vaccines and a greater understanding of how long immunity lasts.
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Professor Helen McShane, the chief investigator, said: “Challenge studies tell us things that other studies cannot because, unlike natural infection, they are tightly controlled.
“When we reinfect these participants, we will know exactly how their immune system has reacted to the first COVID infection, exactly when the second infection occurs, and exactly how much virus they got.
“As well as enhancing our basic understanding, this may help us to design tests that can accurately predict whether people are protected”.
The trial is expected to start in the summer.
Featured Image – Wikimedia Commons
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Luxury Manchester gym Blok confirms permanent closure after weeks of uncertainty
Daisy Jackson
Blok Manchester has announced its permanent closure, weeks after the doors to the premium fitness facility mysteriously closed.
Around a fortnight ago, members began to arrive to their classes to find the gym on Ducie Street locked up and a forfeiture notice on the door – but at the time, Blok said that it was fighting to reopen.
Sadly, in an email sent to members today, its founder has confirmed that the studio is now permanently closed.
Blok – which has several very successful sites down in London – said that its relationship with its landlord has ‘broken down to a point where trust has been lost’.
The gym wrote that it’s been left with ‘no workable way forward’.
They said: “BLOK Manchester was a space built by our loyal and dedicated community. Whether you joined us for one class or one hundred, we are deeply grateful. You helped create something genuinely special in an incredible city.”
In the immediate future, they said they’ll be supporting the team of fantastic trainers who worked here, as well as looking after members.
Members will be contacted within a few hours with options and refunds owed.
Blok Manchester has announced its permanent closure. Credit: The Manc Group
CEO and founder Ed Stanbury said: “While this marks the end of a chapter, we don’t see it as the end of our story in Manchester. We’re already speaking with developers about potential future sites and remain committed to returning to the city when the time is right.
“Thank you for being part of our story so far. Let’s shape the future of wellness. The mission continues.”
Commenting on Blok’s Instagram post – its first in almost a fortnight – people have been sharing their sadness at the closure of its Manchester site.
One person wrote: “beautiful space, beautiful staff and beautiful community.”
Another said: “Sending love to all the instructors !! :(((( gutted”
Someone else commented: “THE BEST CLASSES. I’m gutted.”
‘The average cost of a pint’ in the UK by region, according to the latest data
Danny Jones
Does it feel like pints keep getting more and more expensive almost every week at this point? Yes. Yes, it does, and while you can’t expect a city as big as Manchester to be one of the cheapest places to get one in the UK, we do often wonder how it compares to other parts of the country.
Well, as it happens, someone has recently crunched the numbers for us across the nation, breaking down which regions pay the most and the least for their pints.
The data has been examined by business management consultancy firm, CGA Strategy, using artificial intelligence and information from the latest Retail Price Index figures to find out what the ‘average cost of a pint’ is down south, up North and everywhere in between.
While the latest statistics provided by the group aren’t granular enough to educate us on Greater Manchester’s pint game exactly, we can show you how our particular geographic region is looking on the leaderboard at the moment.
That’s right, we Mancunians and the rest of the North West are technically joint mid-table when it comes to the lowest average cost of a pint, sharing the places from 3rd to 8th – according to CGA, anyway.
Powered by consumer intelligence company, NIQ (NielsenIQ) – who also use AI and the latest technology to deliver their insights – we can accept it might seem like it’s been a while since you’ve paid that little for a pint, especially in the city centre, but these are the stats they have published.
Don’t shoot the messenger, as they say; unless, of course, they’re trying to rob you blind for a bev. Fortunately, we’ve turned bargain hunting at Manchester bars into a sport at this point.
We might not boast the lowest ‘average’ pint cost in the UK, but we still have some bloody good places to keep drinking affordable.
London tops the charts (pretends to be shocked)
While some of you may have scratched your eyes at the supposed average pint prices here in the North West, it won’t surprise any of you to see that London leads the way when it came to the most expensive pint when it came to average cost in the UK.
To be honest, £5.44 doesn’t just sound cheap but virtually unheard of these days.
CGA has it that the average cost of a beer in the British capital is actually down 15p from its price last September, but as we all know, paying upwards of £7 for a pint down that end of the country is pretty much par for the course the closer you get to London.
Yet more reason you can be glad you live around here, eh? And in case you thought you were leaving this article with very little, think again…
The Manc -
19th April 2021 
