In what is a major breakthrough thanks to new research, scientists are claiming they have found a potential cure for hair loss.
With statistics and estimations showing that approximately 85% of men and 40% of women will be affected by hair loss at some point in their lives, researchers at the University of California Riverside have been studying hair follicles in depth to try and find out as much as possible.
In a new study published in the Biophysical Journal, the team at UC Riverside explained that they decided to focus on hair follicles as they’re the only organ in humans that regenerates automatically and regularly, even if they haven’t been injured – and it’s from this research that they they discovered that just a single chemical is the key cause for hair follicle cells dividing and dying.
They discovered a type of protein named TGF-beta.
TGF-beta controls the process in which cells in hair follicles – including stem cells – divide and form new cells, or orchestrate their own death, which eventually leads to the death of the whole hair follicle.
But could this be reversed and successfully cure baldness and heal wounds? Scientists hope so.
Explaining more about the discovery in the study, UC Riverside mathematical biologist and study co-author Qixuan Wang said: “In science fiction when characters heal quickly from injuries, the idea is that stem cells allowed it.
Scientists have discovered a potential cure for baldness thanks to new research / Credit: Tengyart (via Unsplash)
“In real life, our new research gets us closer to understanding stem cell behaviour, so that we can control it and promote wound healing.”
“TGF-beta has two opposite roles,” Wang added.
“It helps activate some hair follicle cells to produce new life, and later, it helps orchestrate apoptosis, the process of cell death.”
While no one is entirely sure why follicles kill themselves, and some hypotheses suggest it’s a trait inherited from animals shedding fur to survive hot summer temperatures, or trying to camouflage, what we do know is that with TGF-beta, as is the same with many chemicals, it’s the amount that makes the difference, and if the cell produces a certain quantity of TGF-beta, then it activates cell division.
Wang continued: “Even when a hair follicle kills itself, it never kills its stem cell reservoir [as] when the surviving stem cells receive the signal to regenerate, they divide, make new cell and develop into a new follicle.”
Of course, there’s still some way to go until baldness is cured – however, researchers have suggested that it may be possible to activate follicle stem cells and stimulate hair growth if more research is carried out on how TGF-beta communicates with other genes and promotes cell division.
If they can find a way to accurately control levels of the protein, then it could lead to an effective treatment for hair loss.
“Potentially, our work could offer something to help people suffering from a variety of problems,” Wang concluded.
Salford City FC have signed an exciting Under-20 World Cup winner on loan
Danny Jones
Salford City FC have quietly done arguably one of the best little bits of business this summer with their new signing, picking up an exciting youth forward and Under-20 World Cup winner on loan.
Announced this week, 21-year-old striker Nicolás Siri has joined Salford City on a season-long loan deal from Montevideo City Torque.
That same season, he scored 10 goals in a total of 30 games across all competitions, before going on to play his first minutes in Europe last term – and now he’s getting a first taste of English football.
Siri, who began impressing at an early age as part of the under-15s national team, began his club career at Danubio FC in 2020.
Joining Montevideo a year later, he secured a loan move to Belgian side Lommel SK, scoring twice in just 10 appearances, becoming a first-team starter.
After being scouted by Salford, who are hoping to have a resurgent campaign, with co-owner Gary Neville targeting promotion to the Championship over the next few years, he is one of several signings made in this ambitious transfer window.
Taking the number 27 shirt, he’s made his first cameo against Cheltenham Town, being subbed on in the 67th minute as the Ammies went on to score a late equaliser thanks to a Kadeem Harris header in the 93rd minute of stoppage time.
Speaking of numbers and stats, Siri boasts a very impressive one; he’s in good company with it, too.
Sitting down with club media after his arrival at the Peninsula Stadium on Thursday, the youngster said: “I’m pleased to be here and I can’t wait to start playing. I’m a player who likes running into space, who constantly tries to hit the target and looking to score as much as I can.
“Lommel was a great opportunity, I really enjoyed it, and it helped me prepare for my next career step in Europe. I believe being here is a great opportunity that I am going to make the most out of, and that I am going to enjoy.
“If you do well at this level, you can set yourself up to have a great career. That’s my goal, and that is what I want to achieve here.”
He speaks with plenty of sense for his age. You can see his first full interview in Salford red down below.
A new music showcase is taking place at a beautiful and historic Stockport venue
Danny Jones
A new live showcase is coming to Stockport town centre as part of a wider music, art and cultural celebration next month.
And by new, we mean the artists; if you went to the last edition, you’ll know it delivers some serious talent.
Teaming up with the likes of Manchester-based music magazine and promoters, The Rodeo, as well as ticketing platform Skiddle, Stockport is set to welcome the return of Mercury Climbing Festival.
This week-long celebration of music, art and culture around parts of the Greater Manchester borough’s historic old town, and there are some exciting names on board already.
As for Mercury Climbing 2025 itself, the multi-day festival spread across several locations boasts the best in native and Northern music, visual arts, and comedy.
Popping up across a total of eight different spaces, including the likes of the brand-new Stockroom, pubs, and headline music venue St Mary’s Church – quietly one of the coolest places we’ve ever seen a gig – you have plenty of reason to be excited about this one.
Speaking of St Mary’s, while artists such as local legends Badly Drawn Boy, Manc indie outfit The Covasettes and Riding The Low – fronted by actor Paddy Considine – are set to play the stunning ceremonial space, The Rodeo is also hosting its own dedicated stage at the church.
Highlighting emerging new talent on Saturday, 20 September, Manchester-based solo indie project Better Joy is set to headline, with Denver County Council (who featured on our Manc artists of the month round-up), Henry Webb-Jenkins, Katie & the Bad Sign, plus more to be announced in support.
The last time we saw a ‘Live at St Mary’s’ event, we can’t stress this enough: it was nothing short of an unforgettable experience.
You don’t get to enjoy a ‘religious’ gig experiences like this often…
Taking place from Friday, 19-26 September, the festival as a whole will transform Stockport’s historic Old Town into a vibrant cultural hub.
And it isn’t just music: there are local food and drink traders getting involved, artwork from the one and only Stanley Chow, as well as plenty of other entertainment.
Above all else, the event is not only steeped in SK and Greater Manchester’s rich heritage, but it’s a great way of supporting new art coming out of the region.
The Rodeo’s St Mary’s stage gets underway from 4pm and is scheduled to finish at 10:30pm, but the wider Mercury Climbing programme is an all-day festival that won’t end until late. You can grab your tickets right HERE.
Emily Sergeant -
26th July 2022 
