A toddler with a rare fatal genetic condition has become the first child in the UK to receive a lifesaving gene therapy treatment on the NHS.
19-month-old Teddi has been treated with a revolutionary gene therapy known by its brand name Libmeldy – which has a list price of £2.8 million, and was the most expensive drug in the world when the NHS negotiated a “significant confidential discount” last year to make the treatment available to patients.
Despite this discount though, it still remains the most expensive drug licensed in Europe – with Teddi being the first child to be given the treatment.
The Northumberland toddler has a rare and fatal genetic disease called metachromatic leukodystrophy (MLD), and was sadly diagnosed with the condition along with her three-year-old older sister Nala in April last year.
MLD causes severe damage to the affected child’s nervous system and organs, and devastatingly results in a life expectancy of between just five and eight years.
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Parents thank Manchester doctors as toddler with fatal disease is saved by world’s most expensive drug / Credit: NHS England
Teddi was treated by a specialist service being delivered at Royal Manchester Children’s Hospital (RMCH) – which is collaboration with Manchester’s Centre for Genomic Medicine at Saint Mary’s Hospital.
The centre in Manchester is one of just five European sites administering the treatment – which works by removing the child’s stem cells and replacing the faulty gene that causes MLD, before re-injecting the treated cells into the patient – and is the only site in the UK.
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NHS England explains that the most common form of MLD usually develops in babies younger than 30 months, and due to the development of a crucial enzyme that leads to a build-up of fats that then destroy the protective layers around the child’s nerves, it can lead to loss of sight, speech, and hearing, as well as difficulty moving, brain impairment, seizures, and eventually death in childhood.
Ally and Jake have two beautiful girls, Nala and Teddi. In April 2022, both girls were diagnosed with metachromatic leukodystrophy (MLD), a genetic disease resulting in a life expectancy of five to eight years.
Teddi was the first person in the UK to receive the Libmeldy treatment outside of a clinical trial – which began when she was 12 months old.
Treatment first began with the removal of stem cells at the end of June, which were then treated before the transplant took place in August, and Teddi was discharged back to her home in Northumberland in October to become “a happy and healthy toddler” now showing no signs of the devastating disease she was born with.
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Sadly though, Teddi’s older sister Nala was not eligible for the treatment, as the clinical guidance requires the gene treatment to be administered before the irreversible damage caused by the disease progresses too far, NHS England explained.
Teddi and older sister Nala were both diagnosed with MLD in April 2022 / Credit: NHS England
Teddi’s mum, Ally Shaw, has praised Manchester doctors for saving her little girl.
“In April last year, our world was turned upside down when not one, but both of our daughters were diagnosed with MLD,” Ally said.
“Being told our first daughter, Nala, wasn’t eligible for any treatment, would continue to lose all functions, and die extremely young was the most heart-breaking and hardest thing to come to terms with. However, amongst the pain, was hope for our younger daughter, Teddi. We were told that a new gene therapy treatment had, luckily, recently been made available on the NHS.
“We are extremely privileged that Teddi is the first child to receive this on the NHS and grateful that she has the opportunity to lead a long and hopefully normal life.
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“Without this treatment, we would be facing both our children being taken away.
“We would like to say a huge thank you to our specialists, doctors and nurses and all the staff at Royal Manchester Children’s Hospital who have been fantastic in caring not just for Teddi, but us as a family.”
19-month-old Teddi has been treated with a revolutionary gene therapy / Credit: NHS England
NHS England has called this “a huge moment of hope” for parents and their babies who are born with this devastating inherited disorder.
Speaking on the success of the treatment, NHS chief executive Amanda Pritchard said: “Thanks to advancements in gene therapies, and the commercial ability of the NHS to strike deals for cutting-edge drugs and then deliver them through our phenomenally skilled specialist staff, children born with this condition now have the opportunity to lead normal, healthy lives.”
Previous treatment options for MLD on the NHS were limited to managing symptoms and providing supportive care.
But now, the new Libmeldy treatment will be available to babies and young children with no clinical signs or symptoms, as well as those with early symptoms of the condition, so long as they can still walk independently and with no evidence of cognitive decline.
Featured Image – NHS England
Manchester
The Streets have just announced a massive outdoor gig in Manchester
Danny Jones
UK hip-hop, garage and grime icons The Streets have become the latest act confirmed for the Sounds of the City musical festival 2026, announcing a huge outdoor gig in Manchester as part of their shows next summer.
One of the most influential bands in the space, having inspired countless others in adjacent genres over the past couple of decades, The Streets are up there with some of the biggest names to ever book Castlefield Bowl.
Revealing a brand new UK tour in line with a special album anniversary, which features just a handful of domestic live dates, we’re counting ourselves very lucky to be on the list.
Big news! The Streets @mikeskinnerltd will perform 'A Grand Don’t Come For Free' in full for the first time at Manchester Castlefield Bowl & @Yourallypally Park in July 2026 🔥
Set to play the fan favourite amphitheatre for the second time, the 46-year-old frontman and legendary British producer is bringing vocalist Kevin Mark Trail, guitarist Rob Harvey, and a number of other regular session players along for the ride.
Other cities being treated to the experience include the likes of London, Bristol and our mates over in Leeds, too.
The tour itself is to mark 20 years since the release of their seminal second album, A Grand Don’t Come For Free, which remains arguably their most important work.
Skinner and his mates join the likes of The K’s in being the first to join the lineup for Sounds of the City 2026; safe to say it’s already off to a good start.
An incredibly well-received follow-up to their already impressive debut, Original Pirate Material, the much-loved 2004 LP is set to be played in full for the first time EVER.
Speaking on the milestone, Skinner said:“A Grand Don’t Come For Free was a moment in time — for me, and for everyone who grew up with it. I wrote it as a story from beginning to end, even studying screenwriting to shape it and without the faintest idea how people would react.
“We’ve been looking for something bold to do with the live show, and we landed here: some tracks have never been played live, others haven’t surfaced in years.
“It’s a new challenge to bring the whole journey to life on stage, but I have an incredible band, and we always give everything every night. So I’m certain we’ll make finding out what happened to that thousand quid a party every night.”
You can see the full list of shows down below.
The Streets live UK tour dates 2026
Friday, June 26, 2026 – Dreamland – Margate
Saturday, June 27, 2026 – Bristol Sounds – Bristol
Saturday, July 18, 2026 – Alexandra Palace Park – London
Thursday, July 23, 2026 – Ludlow Castle – Ludlow
Friday, July 24, 2026 – Kirkstall Abbey – Leeds
Friday, August 7, 2026 – Audley End Estate – Essex
Friday, August 21, 2026 – Rock n Roll Circus – Norwich
You can get ready to grab your tickets for The Streets live for Sounds of the City at Castlefield Bowl by signing up for exclusive artist pre-sale access, or you can just go for general admission when they go live next Friday, 17 October HERE.
Featured Images — Ben Cannon/Press shots (supplied)
Manchester
The Weeknd finally adds Manchester stadium gig to huge tour
Daisy Jackson
The Weeknd has added a whopping seven dates to his upcoming tour – including a stadium gig here in Manchester.
The Blinding Lights singer is taking his The After Hours Til Dawn Stadium Tour to massive venues across Europe next year, but had previously skipped our city in favour of London.
But today The Weeknd has announced a night at the Etihad Stadium next June, along with new dates in Paris, Barcelona, Lisbon, Copenhagem, Munich and Lille.
The diamond-certified global star performed here back in 2023, with a giant moon balloon hanging over the Etihad Stadium.
The 2026 After Hours Til Dawn Stadium Tour was already a 40-date sold-out stadium tour, and now the Live Nation produced tour has added extra stops.
Playboi Carti will appear as The Weeknd’s support act on all EU/UK dates.
The Weeknd adds Manchester gig to upcoming stadium tour
This particular tour celebrates his album trilogy of After Hours (2020), Dawn FM (2022), and Hurry Up Tomorrow (2025).
The Weeknd will perform at the Etihad Stadium in Manchester on 11 June 2026.
Tickets will go on sale via an artist presale and Mastercard presale from 12pm on Tuesday 14 October, followed by a Nespresso presale, and then general sale from 12pm on Friday 17 October.
The Weeknd UK and European dates for After Hours Til Dawn 2026 tour
Thu Jun 11 – Manchester, UK – Etihad Stadium – NEW DATE
Fri Jun 19 – Copenhagen, Denmark – Parken – NEW DATE
Sat Jun 25 – Munich, Germany – Allianz Arena – NEW DATE
Fri Jul 3 – Lille, France – Stade Pierre Mauroy – NEW DATE
Wed Jul 8 – Paris, France – Stade De France – NEW DATE
Fri Jul 10 – Paris, France – Stade de France
Sat Jul 11 – Paris, France – Stade de France
Sun Jul 12 – Paris, France – Stade de France
Thu Jul 16 – Amsterdam, Netherlands – Johan Cruijff ArenA
Fri Jul 17 – Amsterdam, Netherlands – Johan Cruijff ArenA
Sat Jul 18 – Amsterdam, Netherlands – Johan Cruijff ArenA
Tue Jul 21 – Nice, France – Allianz Riviera
Wed Jul 22 – Nice, France – Allianz Riviera
Fri Jul 24 – Milan, Italy – San Siro Stadium
Sat Jul 25 – Milan, Italy – San Siro Stadium
Sun Jul 26 – Milan, Italy – San Siro Stadium
Thu Jul 30 – Frankfurt, Germany – Deutsche Bank Park
Fri Jul 31 – Frankfurt, Germany – Deutsche Bank Park
Sat Aug 01 – Frankfurt, Germany – Deutsche Bank Park
Tue Aug 04 – Warsaw, Poland – PGE Narodowy
Wed Aug 05 – Warsaw, Poland – PGE Narodowy
Sat Aug 08 – Stockholm, Sweden – Strawberry Arena
Sun Aug 09 – Stockholm, Sweden – Strawberry Arena
Mon Aug 10 – Stockholm, Sweden – Strawberry Arena
Fri Aug 14 – London, UK – Wembley Stadium
Sat Aug 15 – London, UK – Wembley Stadium
Sun Aug 16 – London, UK – Wembley Stadium
Tue Aug 18 – London, UK – Wembley Stadium
Wed Aug 19 – London, UK – Wembley Stadium
Sat Aug 22 – Dublin, Ireland – Croke Park
Sun Aug 23 – Dublin, Ireland – Croke Park
Fri Aug 28 – Madrid, Spain – Riyadh Air Metropolitano
Sat Aug 29 – Madrid, Spain – Riyadh Air Metropolitano
Sun Aug 30 – Madrid, Spain – Riyadh Air Metropolitano
Tue Sep 1 – Barcelona, Spain – Estadi Olímpic Lluís Companys – NEW DATE
Sat Sep 5 – Lisbon, Portugal – Estadio do Restelo – NEW DATE