An eight-year-old Cheshire girl with a rare degenerative disease has become one of the first to receive a pioneering new treatment that will attempt to save her eyesight.
Amelia Carroll, from Poynton near Stockport, was diagnosed with CLN2 Batten disease – an incurable and fatal condition that affects roughly around 30-50 children in the UK – when she was just two.
The disease is caused by a change in a gene that is responsible for making a specific enzyme in the nervous system, and it results in seizures, a gradual decline in a child’s ability to walk, speak and see, as well as progressive dementia.
Amelia’s 11-year-old brother Ollie also has the same condition, yet has sadly already lost his eyesight.
“We have watched our son Ollie go blind, and now the same is starting to happen to Amelia,” mother Lucy Carroll explained, which is why her and her husband Mike decided to contribute to a fundraising campaign together with families of other children affected by the disease alongside the Battens Disease Family Association (BDFA) to help fund a world-first trail of a groundbreaking new treatment at Great Ormond Street Hospital (GOSH).
ADVERTISEMENT
Over £200,000 was raised through the campaign, and clinicians and researchers at GOSH and ICH say the treatment programme has the potential to transform the quality of life for children living with CLN2 Batten disease.
Amelia became one of the first children in the world to receive the treatment, and is said to already be responding to it “perfectly”, CheshireLive reports.
For the past two years, enzyme replacement therapy has been used to help prevent neurological deterioration in children with CLN2 disease. The drug, called Brineura, was first approved for use on the NHS in 2019 and is administered directly into the brain by a regular infusion.
It has shown to restore enzyme activity and slow the onset of disability.
However, this infusion into the brain does not prevent children going blind, as the enzyme cannot cross the blood-retina barrier, and this means that the nerves in the eye cannot function and vision is lost, which is why clinicians and researchers at GOSH and ICH are trying a the treatment to prevent the onset of blindness instead.
ADVERTISEMENT
To do this, GOSH said they are using the tiny amount of the drug leftover from the brain infusion and injecting it directly into the back of the eye.
The 18-month treatment trail – which is said to be being given on a compassionate use basis – hopes to prevent eyesight deterioration in children by providing the enzyme that the nerves in the back of the eye need to function.
Ms Carroll said “to save a child’s sight would be incredible”, and if it does indeed work, it would “make such a big difference to Amelia’s quality of life”.
“We just pray it works,” she added.
Speaking on the groundbreaking treatment trail, Professor Paul Gissen, from GOSH and the UCL GOS Institute of Child Health, said: “If successful, we hope our work can pave the way to saving the sight of more children with this disease to preserve their quality of life for as long as possible.”
ADVERTISEMENT
Amelia’s father, Mike Carroll, said the “amazing” nurses and doctors treating his daughter were “incredible”.
GMP officer sentenced after hitting pedestrian during police chase in Rochdale
Emily Sergeant
A police officer has been sentenced this week after he struck and ‘seriously injured’ a pedestrian following a pursuit of a suspected drink driver in Rochdale.
35-year-old Greater Manchester Police (GMP) officer PC Sam Lockley pleaded guilty back in January 2026 following an Independent Office for Police Conduct (IOPC) investigation.
The IOPC investigation established that, in the early hours of the morning on 19 November 2023, PC Lockley was driving a marked police vehicle with the lights and sirens activated, and attempted to stop a suspected drunk driver on Drake Street in Rochdale.
A short pursuit that commenced but stopped merely a minute later after the police vehicle collided with a pedestrian on the footpath of Rochdale Road at approximately 3:30am.
The evidence gathered indicated that PC Lockley failed to slow down as he approached and drove through the red traffic lights at the Kingsway junction, and was travelling at a speed of 96mph in a 30mph zone.
The pedestrian suffered ‘serious injuries’ as a result of the collision, and received extensive medical treatment following.
At a hearing back in February of this year, PC Lockley received a two-year suspended sentence and was ordered to carry out 15 days community service, while also receiving two-year driving disqualification.
Also following the investigation, the IOPC decided that Lockley should face a gross misconduct hearing to face allegations that his manner of driving breached the police standards of professional behaviour.
“We continue to liaise with the force about disciplinary proceedings,” the IOPC concluded.
IOPC Director Amanda Rowe added: “My sympathies remain with the man, who sustained serious injuries, and all those affected by the incident.
“This was a complex investigation which relied on extensive amounts of data and expert analysis and the evidence showed PC Lockley drove at excessive speeds at night-time and although he was responding to a report of a suspected drink driver, it does not excuse his manner of driving.
“PC Lockley admitted he drove in a dangerous manner when he didn’t address hazards or warnings during the pursuit and ultimately by the time he saw the pedestrian, he was travelling too fast to avoid a collision.
“His actions that day have had long-lasting consequences and he has now been held accountable.”
Featured Image – Rawpixel
News
Manchester Town Hall is FINALLY taking wedding and events bookings for the first time since 2018
Emily Sergeant
A new era is on the horizon, as Manchester Town Hall has announced that it’ll be finally taking bookings for weddings and events once again.
That’s right… for the first time since it closed its doors to the public for what is the UK’s biggest restoration project to date back in 2018, one of Manchester’s most iconic landmarks is soon set to welcome its first weddings and events in a decade – with bookings for the city’s most romantic address now open once again.
Manchester Town Hall has stood at the centre of civic life in the city since 1877, and for generations, couples have exchanged their vows within its walls.
Now, as it enters the home stretch of its restoration, the Grade I-listed building is gearing up to kickstart weddings and corporate events from January 2028.
Set reopen to the public next year, first up will be a series of celebratory reopening events – which are yet to be announced – before a phased approach will then allow the building and teams to be fully prepared to host commercial events again from 2028.
Manchester Town Hall has announced that it’s finally taking wedding and events bookings for the first time since 2018 / Credit: Supplied
From its grand architecture and soaring stained glass windows, to sweeping staircases that offer the perfect ‘just married’ photo opportunities, this one-of-a-kind venue gives couples the opportunity to combine the romance and grandeur of a historic setting with the energy of a city centre celebration.
Inside the restored building, you’ll find The Great Hall, which is a magnificent setting with striking architectural character, as well as The Conference Hall, The Banqueting Hall, and The Reception Room, all of which offer equally characterful spaces that are perfect for private dinners, ceremonies, or corporate events.
The Lord Mayor’s Parlour is one of many settings overlooking the newly reopened Albert Square, while various elegant reception areas provide the perfect location for drinks and arrival moments.
“Our Town Hall is a real Victorian masterpiece and we’re looking forward to sharing it with the public once again,” explained Cllr Garry Bridges, who is Leader of Manchester City Council, as bookings finally open up this week.
“It’s a special building which belongs to the people and it’s great that they will be able to celebrate important landmarks in their lives, such as marriage, in its spectacular setting.
“The Town Hall is full of history. Here’s to many more stories being written within its walls.”
Want to be one of the first people who gets married or hosts an event at Manchester Town Hall once it reopens in 2028? You can enquire about booking here.
Emily Sergeant -
14th January 2022 
