Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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Microdot exhibit for BRITs 2026: the artwork of Oasis, Verve and more up in Manchester Piccadilly
Danny Jones
If you’ve passed through Manchester Piccadilly of late, you might have noticed two things: one, it’s really quiet, and two, there’s loads of cool Britpop merch and memorabilia on display, including original Oasis, The Verve, Inspiral Carpets art and more – all courtesy of Microdot.
Set up as part of the city’s own BRITs celebrations, along with a raft of other nationwide festivities, as the annual music award ceremony prepares to make its Manc debut at the Co-op Live this month, the showcase features special edition frames and more, all pride of place in the middle of the train station.
This collection, simply entitled ‘A Microdot Design’, is all done by the legendary Brian Cannon, the graphic designer and art director behind so much recognisable visual material within the genre.
We recently had the honour of speaking to the man himself in person ahead of Piccadilly’s temporary closure; you can see our interview with him right here:
The Wigan-born artist and visionary didn’t just make promotional materials for some of the biggest bands in the 1990s; he’s responsible for what has gone on to become some of the most familiar iconography in British music history.
With this pop-up exhibit available for a limited time only, we strongly urge you to go along and, for once, take your time rather than rushing around the station as you peruse the boards placed right near the main entrance.
Charting his work from circa 1990 up until now, it’s crazy to see just how many of Brian and Microdot’s fingerprints are all over so many different bands and artists.
From native names like Oasis, The Verve and the Inspirals, as mentioned, as well as the likes of Cast, Super Furry Animals, Suede and Ash, plus so many more, this guy has been nothing short of prolific over the past few decades.
Audio North took a little tour of the King Street South unit last year in the lead-up to Oasis Live ’25 reunion world tour, and we felt like kids in a Britpop sweetshop.
While this site has sadly since closed, shutting up shop back in July, Brian’s mini, modest, but nevertheless magic Microdot Boutique up in the Lake District is still standing.
Located in the popular North West town and tourist attraction, Kendal, it’s worth a trip there to see more of his portfolio alone.
Currently on display at Manchester Piccadilly ahead of the full 2026 BRITs Week and shindig at Co-op Live, it’s one of the best completely free things you can do in town at the moment – but the exhibition finishes on Sunday, 1 March, so make sure you don’t miss it.
Speaking of the BRIT Awards, if you’re wondering what else is on as 0161 gets ready welcome them for their two-year stint (at least), look no further…
Two brothers from Oldham are beating out the likes of Taylor Swift in the iTunes charts
Danny Jones
A pair of brothers from Oldham who simply go by Two Connors are now holding on to the top spot in one of the biggest iTunes charts, and they’re beating the likes of Taylor Swift, Bruno Mars, Bad Bunny and many more.
Stuff your global music stars, we’ll back a duo from Greater Manchester all day long.
Danny and Callum Connor, a couple of blokes from Oldham in their mid-30s, are currently number one in the iTunes singles charts with their latest song, ‘Familiar Faces’, but this isn’t the first time they’ve gone big with a release online.
Carving out their own little corner not only in the old Lancashire borough but a small pocket in the UK’s wider grime, drill, rap and hip-hop scene, they’ve only gotten bigger over the last 18 months or so.
After releasing their first two tracks back in 2024, Callum and Danny have been on a very gradual rise, but they quickly gained a cult local following in and around Oldham.
Writing about life and around the area, with high personal and anecdotal lyrics that feel like niche references and in-jokes specifically for‘Roughyed’ residents – it’s not just music by them but FOR them.
In addition to recording their own unique cover of ‘Bad Habits’ by Ed Sheeran, they also went fairly viral for releasing a music video featuring crowds of local children.
Putting their own chant-based chorus slant on ‘Hi Ho, Hi Ho, “It’s off to Work We Go”‘, written by Mitch Miller and The Sandpipers (yes, as in the main theme from Snow White and the Seven Dwarfs), it was a fairly radio-friendly tune that was easy for kids and more to sing along with.
With various other natives getting involved in the music video, joining them on the town centre streets and lip-syncing the lyrics, it was circulated online all over Britain and beyond.
You can watch it in full down below.
Fast forward to February 2026, and not only have they grown their following across the region, but even further afield now, as it turns out; currently sitting ahead of ‘Opalite’ from worldwide smash-hit album, The Life of a Showgirl, who needs big label backing, eh?
Bringing smiles to even more Greater Mancs by quite literally shining the spotlight on ‘Familiar Faces’ and punters from nearby pubs such as The Up Stepps Inn and former nightclub Sruples, it is a real tribute to their homeland.
Only time will tell how long they’ll cling to that iTunes top spot, but with nearly 73,000 monthly listeners on Spotify and counting, they might be one of the biggest music names to come out of OL in some time.
In other big news over in Oldham, on the sporting side of things, RLFC are staring down yet more uncertainty, with local hero Bill Quinn also wrapping up his time at the club.
Daisy Jackson -
30th November 2022 
