Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
ADVERTISEMENT
They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
ADVERTISEMENT
“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
ADVERTISEMENT
“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
ADVERTISEMENT
“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
News
The Boots recycling scheme where you can get £5 off every shop
Thomas Melia
UK high street retailer and healthcare shop Boots has launched an innovative recycling scheme that entitles customers to £5 off their future shopping trips.
If you’re still struggling to come up with a New Year’s resolution, why not try a spot of recycling and earn some money off your next cosmetics shop while you’re at it?
Started in 2020, the Boots Recycling Scheme allows Advantage Card holders the opportunity to get money while also being more conscious about how we recycle our used health and beauty products.
Their third-party app, Recycle at Boots, uses a ‘Scan2Recycle‘ system where users can upload items from various beauty brands by taking a picture of the empty packaging before identifying its form.
This scheme takes items that can’t usually be recycled at home, such as lotion pumps, toothpaste tubes, lipstick, mascaras, travel minis, make-up palettes and more.
Once you have five items approved, head over to your nearest participating Boots store, drop off your empties and scan the QR code on the deposit box.
After you’ve followed all these steps, a voucher will appear entitling you to 500 Advantage Points when you spend £10 in-store at your nearest location, and not only do you have £5 worth of points with your name on it, you’re also an eco-warrior.
There’s even a dedicated section of the app to recycling empty medicine and vitamin blister packs, which gives customers 100 Advantage Points when they spend £5 in-store.
Brilliant.
Credit: Publicity pictures (supplied)
Items dropped into these deposit boxes are taken to MyGroup, a recycling and waste management service which works around the clock to help divert waste from landfill.
These empties will be washed and traditionally recycled into a material called MyBoard, a construction board material most similar to plywood, with lots of different uses.
Nearest Boots locations in Manchester running the Recycle at Boots scheme:
Manchester Market Street – 32 Market Street, M1 1PL
Salford Regent Park – Regents Park, M5 3TP
Manchester Didsbury – 736-740 Wilmslow Road, M20 2DW
The Trafford Centre – 10 Peel Avenue, M17 8BD
Trafford Retail Park – Neary Way, M41 7FN
If you’re up for getting money off your next Boots splurge while also helping recycle cosmetics containers and more, you can download the Recycle at Boots app and find your nearest HERE.
Manchester United issue statement after Bruno Fernandes’ social media is hacked
Danny Jones
Manchester United were forced to issue an official statement following Bruno Fernandes’ social media being hacked.
The Man United star’s digital profile was hijacked in the wake of the defeat to Brighton and Hove Albion this weekend, which saw the Red Devils knocked out of the FA Cup and, it’s fair to say, quite the flurry of activity online.
As if to add insult to injury, with United‘s exit from the competition, a user then commandeered the club captain’s presence to share several fake posts.
With the official Bruno Fernandes X account being targeted following the game, the club had no choice but to respond after several controversial and/or inappropriate posts, not to mention multiple instances of general anti-ownership sentiment.
In case you didn’t see any of the since-deleted posts, besides one understandably troublesome comment which read, “let’s get rid of INEOS“, others were even more provocative/inflammatory.
The comments ranged from everything between messages @ing darts player and United fan Luke Littler to influencers like KSI and Jake Paul.
Offensive language was also present in many of them.
As for the Portuguese midfielder, he also quickly clarified that he obviously had no involvement in the activity; meanwhile, despite plenty of players coming out to apologise for the defeat on Sunday night, the skipper is yet to address the disappointment directly.
The loss to Brighton confirmed that Manchester United will be playing just 40 games for the rest of the campaign – the fewest since the 1914/15 season (i.e. at the outset of the First World War) – which serves as yet another unwanted record for the club of late.
You can see the highlights for the game down below.
It is also likely to have been caretaker manager Darren Fletcher’s final game in charge of the Reds, with an interim replacement set to be appointed imminently following Ruben Amorim’s shock sacking earlier this month.
His predecessor, Ole Gunnar Solskjær, also looked like the frontrunner at one point – and could still be involved in a backroom setup – but The Athletic now has it that Carrick could be is odds-on favourite to be announced before the Manchester derby.
Nevertheless, plenty of supporters still feel the problems remain deeply rooted throughout the club and that a change of personnel among the coaching staff still may not be enough…
Daisy Jackson -
30th November 2022 
