Alzheimer’s Research UK has hailed the drug lecanemab as a ‘truly historic moment’ for dementia research after trials found it can slow the rate of decline in people’s memory.
Results from a three-phase clinical trial have been published today by pharmaceutical company Eisai.
The data has shown that the drug can help Alzheimer’s patients over 18 months and help them with day-to-day activities.
The trial included 1,795 people in the early stages of the disease, who received bi-weekly infusions of either lecanemab or a placebo.
Alzheimer’s Research UK has said that the findings represent a ‘major step forward’ for dementia research.
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They noted, however, that lecanemab did come with significant side effects.
Credit: Unsplash
Dr Susan Kohlhaas, Director of Research at Alzheimer’s Research UK, said: “These exciting findings represent a major step forward for dementia research and could herald a new era for people with Alzheimer’s disease. This is the first time a drug has been shown to both reduce the disease in the brain and slow memory decline in clinical trials.
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“Lecanemab works by clearing the amyloid protein that builds up in the brain in people with Alzheimer’s disease. In this trial, the drug slowed down participants’ decline in memory and thinking, and their ability to carry out day-to-day activities. Although the benefits were small and came with significant side effects, it marks the arrival of a treatment that can slow the course of Alzheimer’s disease.
“With all this excitement, there are still many questions and challenges we need to address.
“The treatment window in the trial was for 18 months, so we don’t yet know whether there will be impacts to people that last beyond this. Longer-term studies that are ongoing will tell us whether the modest improvements seen in the trial change the trajectory of the disease longer-term.
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“Lecanemab was associated with severe side effects, and it will be important for regulators to understand the safety profile of the drug before it is given a full license for use.
“The benefits of taking lecanemab in the trial were modest but the challenge and opportunity remains within dementia research to build on these findings into an era where we’re developing multiple treatments against different aspects of Alzheimer’s disease to slow and stop the disease.
“It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them. We recommend, through the new Dementia Mission, the government take urgent steps to bring together regulators, industry, clinicians and decision-makers in our health system to put a clear plan in place to ensure people in the UK are among the first in the world to access new treatments once they are licensed.
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“This is truly a historic moment for dementia research. This year is the 30th anniversary of the seminal work that revealed the central role of amyloid protein in Alzheimer’s. The road to an anti-amyloid treatment has been a long one and people with Alzheimer’s have seen many disappointing setbacks.
“We hope that this drug will make it to patients, but it won’t be suitable for everyone with Alzheimer’s, and it’s only a first step on the journey towards a cure.”
Featured image: Unsplash
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Historic hidden library in Manchester city centre reveals £11m transformation plans
Emily Sergeant
Ambitious plans to transform one of Manchester’s greatest historical hidden gems have been announced.
Founded all the way back in 1806, The Portico Library – which is hidden in plain sight on Mosley Street, in the heart of the city centre – played a central role in Manchester’s rise as the world’s first modern city, and since then, it has been serving as a window into the past and a providing a place of inspiration for anyone who needs it.
But now, these new transformation plans, titled The Reunited Project, will ensure the building not only survives, but also thrives as the UK’s most sustainable historic library for generations to come.
The Portico Library‘s transformational scheme is supported by The National Lottery Heritage Fund, and will look to ‘reunite’ the historic building’s three floors for the first time in over a century, creating a fully-accessible and sustainable cultural library.
Crucially, plans will see a step-free entrance and lift installed to make the library accessible to all.
There’ll also be new exhibition and event spaces introduced as part of the scheme to explore the stories of Manchester’s communities and the city’s heritage.
There will a Northern Bookshop, showcasing regional and emerging writers, and independent publishers, as well as a creative Portico Kitchen, which will celebrate the city’s food culture, writing, and history.
A place for school groups, families, and all people to explore Portico’s collection and experiment creatively also forms part of the plans.
“Portico Reunited is about more than restoring a building,” explained Dr Thom Keep, who is a Librarian & the Chief Executive of the Portico Library, after the transformation plans were submitted to Manchester City Council.
“It’s about opening doors to stories, ideas, heritage and communities across Greater Manchester.
“These plans secure Portico’s future, unlocking the power of heritage to inspire Manchester’s visitors and residents to explore, share, and celebrate their stories and the city’s literary and global heritage.”
If the plans are approved by the Council, The Portico Library will close for around 18 months for construction, during which it will continue to engage the public through its ‘Portigo !’ pop-up programme.
Featured Image – Portico Library
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Government announces homebuying overhaul to fix country’s ‘broken’ housing system
Emily Sergeant
The Government has announced what it’s calling the biggest shakeup to the homebuying system in this country’s history.
In a bid to ‘rewire a chaotic system which has become a barrier to homeownership for thousands nationwide, the Government has today (Monday 6 October) unveiled proposals that it says will speed up the long-drawn out and costly process of buying a home by four weeks.
The Housing Secretary says this will not only save people money, but unnecessary stress too.
The proposed new plans would see sellers and estate agents required to provide buyers with ‘vital’ information about a property upfront – including the condition of the home, leasehold costs, and chains of people waiting to move.
It’s hoped this will help end any last-minute chain collapses and ultimately give greater confidence to first-time buyers when they’re making one of life’s most important decisions.
The Government has announced plans to fix the country’s ‘broken’ housing system / Credit: Benjamin Elliott (via Unsplash)
Binding contracts could also be introduced to stop people walking away from agreements after buyers painstakingly spend months in negotiations to hopefully halve the number of failed transactions.
The new reforms are also proposing that prospective buyers are provided with side-by-side information on estate agents and conveyancers, including their track record and expertise, alongside new mandatory qualifications and Code of Practice to drive up standards and work to rebuild trust in the industry.
Prime Minister Keir Starmer took to Twitter this morning to address the proposed new homebuying overhaul, commenting: “I promised that my Government would fix the broken housing system.
“Buying or selling a home will be faster, unlocking the dream of homeownership and allowing hardworking people to focus on the next chapter of their lives. That’s national renewal.”
I promised that my government would fix the broken housing system.
Buying or selling a home will be faster, unlocking the dream of homeownership and allowing hardworking people to focus on the next chapter of their lives.
Daisy Jackson -
30th November 2022 
