Researchers are looking for participants to test a potential new treatment for OCD
Volunteers taking part will be reimbursed for their time (including reasonable travel costs) and may be offered the study medication free of charge for 48 weeks.
A leading clinical research organisation is running a clinical trial to test a potential new medication for people living with OCD.
According to the NHS, it is estimated that a quarter of a million people are living with OCD in the UK at some point in their lives, that’s equivalent to 12 in every 1,000.
This number increases drastically when we consider those who haven’t received a diagnosis who could be living with OCD symptoms and not receiving the professional support they may need or understand why they are experiencing intrusive thoughts.
Dr Alex Worthington, Clinical Research Physician at MAC Clinical Research, explains that “obsessive-compulsive disorder, commonly referred to as OCD, is a mental health condition with three main parts: obsessions, emotions, and compulsions.
For #OCDWeek, we wanted to highlight some statistics and information to raise awareness of #OCD.
If you have OCD and are having little to no response to your current antidepressant treatment, you may be eligible to take part in a clinical trial.
“Obsessions are persistent thoughts, images, doubts, worries, or urges that intrude on an individual’s mind, despite being unwanted.
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“These thoughts can cause significant mental discomfort or anxiety. Some of the emotions felt due to intrusive thoughts can include guilt, depression, and disgust.
“Compulsions refer to repetitive behaviours that an individual engages in to temporarily alleviate the anxiety caused by the obsession. Examples of compulsions include checking if a door is locked multiple times or repeating certain phrases mentally.”
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There’s a need for more effective treatment options for OCD, which is why award-winning clinical research organisation, MAC Clinical Research is conducting a clinical trial to test a potential new treatment that is hoped to reduce OCD symptoms and ultimately improve quality of life.
Here at MAC, our OCD clinical trial is open for people struggling with OCD symptoms.
Eligible participants will receive up to £490 plus reasonable travel expenses.
If you or someone you know has been living with OCD or OCD symptoms, and provided you meet the overall criteria, you could be reimbursed up to £490 for your time and participation in the clinical trial plus reasonable travel expenses.
If the treatment works, you may be able to receive nearly a year’s worth (48 weeks) of the medication free of charge as part of an open-label extension study.
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You can find out more and register your interest HERE.
As explained in the summary for this clinical trial, “people with OCD tend to have signalling pathways in the brain which are overactive, causing intrusive thoughts, compulsive behaviour or other OCD symptoms.
“Previous clinical trials suggest that the study medication works to dampen down these overactive pathways which may help people with OCD when used in combination with their usual antidepressant medication.”
The study is expected to run for approximately five months. The trial itself will involve taking the oral medication or a placebo daily for ten weeks alongside seven visits to the clinic for check-ups to examine if your OCD symptoms improve and how well you are coping with taking the medication.
As part of International OCD Awareness Week, MAC also looked intohow the condition affects people in the workplace and answered some of the public’s pressing questions surrounding the disorder with one of the organisation’s leading psychiatrists, Dr David Gregory.
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One of MAC’s leading psychiatrists sheds light on OCD treatment.
To ensure optimal safety, each study participant must meet a pre-determined set of eligibility criteria. To be eligible for the trial, you need to:
Be aged between 18-65
Have had OCD symptoms or an OCD diagnosis for at least 1 year that affects daily life.
Be taking an antidepressant for your OCD that isn’t fully helping.
To ensure optimal patient safety, participants must not have any of the following:
Bipolar, schizophrenia, autism, Tourette’s, or other psychiatric conditions
Diagnosed with an eating disorder.
Have diabetes that requires insulin.
Other criteria will apply.
If you want to learn more about MAC Clinical Research or if you’re considering being part of the clinical trial, you can learn more and register your interest by visiting their OCD research webpage.
For #OCDWeek, we wanted to share what some of our clinical trial participants said made them want to take part in OCD clinical research with MAC.
Featured Image — MAC Clinical Trial/The Manc Group
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Yard & Coop – The Manchester institution taking the Christmas Markets by storm… again
Harry Quick
Firm favourite Manchester restaurant Yard and Coop is back on the Manchester Christmas Markets this year, giving us our annual fix of fried festive favourites – and they’re clucking lovely.
Their restaurant – a staple favourite in the Northern Quarter – is also whipping up some incredible festive specials.
Yard & Coop Christmas Markets
Yard and Coop at the Manchester Christmas Markets. Credit: The Manc GroupYard and Coop at the Manchester Christmas Markets. Credit: The Manc Group
The much-loved Northern Quarter establishment, famed for its buttermilk fried chicken, has pitched up once again on St Ann’s Square.
They’ve whipped up a menu of their classic chicken dishes, each with a festive twist, and you don’t have to look far to see someone walking around with a cone full of the fried stuff.
This chicken institute has made some of the best salt and pepper-loaded fries around. The sticky sweet soy sauce coats the fries along with a heavy dusting of the salt and pepper blend and crispy deep-fried seaweed. Obviously, they are loaded with pieces of buttermilk chicken breast, but that goes without saying.
Yard and Coop at the Manchester Christmas Markets. Credit: The Manc Group
It’s the most wonderful time of the year and the ‘Dirty Santa’ tray was certainly that. Fried chicken and fries covered in lashings rich chicken gravy, hot cranberry sauce and a sprinkle of parsnip crisps for a texture sensation. Even after eight billion mince pies I reckon Father Christmas would have room for these.
A returning favourite has rightfully made its way back onto the menu too. Chicken and fries piled high inside a waffle cone drizzled with BBQ and ranch sauce. It’s a bit of a messy one but that’s the whole point – you eat the cone at the end, so you clean up your own mess!
Yard & Coop festive restaurant specials
All systems are still a-go back in their Northern Quarter base in time for Christmas. Everything is better inside a Yorkshire pudding, right? Well, this festive craze has been beautifully adapted to incorporate Yard and Coop’s signature buttermilk chicken.
It’s Christmas dinner with all the trimmings wrapped in a soft Yorkshire burrito. Oh, and there’s a massive pot of chicken gravy to dip if you weren’t hungry enough reading this.
If you want to go the whole nine yards, the ‘Winner Winner Christmas Dinner’ is back and better than ever. Fully loaded with fried chicken breast, crispy fried potatoes, cheesy mash topped with homemade stuffing balls, creamed sprouts, cranberry hot sauce and buttered kale.
Sprouts are famously a bit hit and miss, aren’t they? Well, not these. Even the most devout brussels sprout hater would be converted by Yard and Coop’s homemade sprout bhajis. This little taste of India accompanies the real showstopper of the selection.
Yard and Coop’s ‘Boxing Day Burger’ transports you to that post-Christmas takeaway slapped between a seeded brioche bun. The signature fried chicken is smothered in their Ruby Murray sauce and stacked alongside cucumber raita salad, a couple of mini poppadoms and those delightful bhajis. Good luck getting it all in one bite, it’s a biggun.
You can find Yard and Coop on Edge Street and at St Ann’s Square at the Manchester Christmas Markets until 21 December.
The charming Manchester Italian restaurant ready to serve a Christmas Day feast
Harry Quick
Italiana Fifty-Five is opening its doors on Christmas Day, helping you indulge in three courses of great food and festive spirit – the Italian way.
Formerly known as the foodie favourite Cibo, diners can step into little Italy rejuvenated with a modern touch.
Its two locations across the city centre, found on Liverpool Road and Great Northern, as well as its restaurant in Didsbury, serve up a tantalising selection of hearty dishes in a sleek and trendy setting.
As well as offering an authentic Italian Christmas Day feast, Italiana 55 will be open a Christmas Party Menu in the lead-up to the big day for all your earlier celebrations.
To begin your Christmas Day feast choose between Zuppa Di Barbavietole E Carote (roasted parsnips and carrot soup); Burrata E Fig (burrata with fresh figs, parma ham and honey); Melanzane Parmigiana (an oven-baked dish made from aubergine, scamorza, tomato, basil and parmesan cheese); Carpaccio Di Manzo (fillet of beef thinly sliced with rocket, parmesan and a homemade dressing); and Arancini V (Sicilian rice balls stuffed with mozzarella and butternut squash).
Antipasti platter at Italiana 55. Credit: The Manc GroupInside Italiana 55 in Manchester, which is open on Christmas Day. Credit: The Manc GroupSteak and risotto feature on Italiana 55’s Christmas menu
Italiana 55’s festive dining experience combines a British-Italian fusion with their selection of traditional mains using locally sourced ingredients with a Sicilian touch.
For your main, you can tuck in to a Tacchino Arrosto – British turkey with potatoes, carrots, sage stuffed sausage served with gravy and cranberry sauce).
Or for a more Italian twist on your celebrations, you can go for Risotto Con Butternut (roasted butternut squash risotto with thyme and parmesan shavings); Capesante Gratinate (seared king scallops topped with grated Parmigiano and a tomato sauce finished under the grill); Filleto Al Ferri (200g 28-day aged Aberdeen Angus fillet served with fries and garlic butter sauce); Ravioli Di Spinaci (egg ravioli filled with ricotta and spinach in a butter and sage sauce); and Rollata Di Pollo (chicken fillet filled with spinach mascarpone and goat cheese in a cream and mushroom sauce).
Rollata Di Pollo on Manchester restaurant Italiana 55’s Christmas menuTiramisu at Italiana 55. Credit: The Manc Group
There is always room for dessert at Christmas, and nobody does it like the Italians.
Nothing screams tradition like a Tiramisu (classic homemade savoiardi biscuits soaked in coffee liqueur and layered with a mascarpone mousse); Vanilla Cheesecake (homemade with fresh vanilla pods, topped with a berry compote); Sticky Toffee Pudding (sponge mixed with dates and raisins, topped with sugar-coated walnuts and drizzled with warm toffee sauce); Gelato (homemade gelato serving vanilla, chocolate strawberry and pistachio); or Profiteroles (buns of choux pastry filled with chantilly cream and topped with a rich chocolate sauce).
If you’ve got a sweet tooth they’ve covered all bases.
You can get all this at Italiana 55 on Christmas Day for £65 per person (adult) and children eat for £30.
So if you’re looking to book a restaurant for Christmas day in Manchester, find out more about Italiana 55 and book here.
Danny Jones -
16th November 2023 
